LRIF1 and EIF6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRIF1	EIF6
Description		ligand dependent nuclear receptor interacting factor 1	eukaryotic translation initiation factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Nucleus Nucleoplasm Chromosome Nuclear Matrix Centriolar Satellite	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Synapse Extracellular Exosome
	Molecular Function	Protein Binding Nuclear Retinoic Acid Receptor Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translation Translational Initiation Response To Insulin MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Ribosome Biogenesis Cytosolic Ribosome Assembly Ribosomal Large Subunit Biogenesis Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs			Copper
Diseases
GWAS		Bone mineral content ( 31790847) Intraocular pressure ( 30591961)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		143 interacting genes: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BANP BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRACR2A CRADD CRCP CRCT1 CRIPTO DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FHL2 FOSL2 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 H3-4 HAP1 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NOC2L NR3C1 NRBP1 NTAQ1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR1C POLR2C POLR3F PPARG PQBP1 PRKAB2 PRKAR2A PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SNU13 SPATA18 SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSEN15 TSPAN6 UBE2V2 UNC119 VIM VPS26C WDR62 WWC1 ZNF24 ZNF410	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		55791	3692
HPRD ID		17975	04221
Ensembl ID		ENSG00000121931	ENSG00000242372
Uniprot IDs		Q5T3J3	P56537
PDB IDs			6LQM 6LSR 6LSS 6LU8 7OW7 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8OHD 8OJ0 8OJ8 8RL2 9GMO
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Protein Binding Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Binding Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Nuclear Receptor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Apoptotic Process Nucleolus Negative Regulation Of Transcription By RNA Polymerase II Biological_process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Development Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Hemopoiesis Chromatin Organization Regulation Of Cell Differentiation Mononuclear Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation DNA-directed RNA Polymerase Activity Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Cycle Process Regulation Of DNA Repair Regulation Of Cell Cycle G1/S Phase Transition	Calyx Of Held Identical Protein Binding Regulation Of Proteolysis Regulation Of Translation Negative Regulation Of Gene Expression Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Viral Life Cycle Translation Anaphase-promoting Complex Binding Negative Regulation Of Cell Size Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Viral Process Mitotic Nuclear Membrane Disassembly Centriolar Satellite Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Post-transcriptional Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemokine Production G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Receptor Internalization Negative Regulation Of Viral Process Double-stranded RNA Binding Membrane Disassembly Spindle Organization Nuclear Membrane Disassembly Endoplasmic Reticulum Unfolded Protein Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endocytosis Antiviral Innate Immune Response Postsynaptic Density Organization Negative Regulation Of Translation Protein Disulfide Isomerase Activity Ribosome
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