LRIF1 and DDIT4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRIF1	DDIT4
Gene Name		ligand dependent nuclear receptor interacting factor 1	DNA-damage-inducible transcript 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Microtubule Organizing Center Actin Cytoskeleton Nuclear Matrix	Intracellular Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Retinoic Acid Receptor Binding	14-3-3 Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Response To Hypoxia Neuron Migration Brain Development Cell Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Negative Regulation Of TOR Signaling Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Complex Disassembly Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		129 interactors: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRADD CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 HAP1 HIST3H3 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NHP2L1 NOC2L NR3C1 NRBP1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR2C POLR3F PPARG PQBP1 PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSPAN6 UBE2V2 VIM WDR62 WWC1 ZNF24	5 interactors: GSK3B HSPA4 LRIF1 PDPK1 TXNIP
Entrez ID		55791	54541
HPRD ID		17975	09662
Ensembl ID		ENSG00000121931	ENSG00000168209
Uniprot IDs		Q5T3J3	Q9NX09
PDB IDs			3LQ9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Metabolic Process System Development Regulation Of Gene Expression Developmental Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Multicellular Organismal Development Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Nervous System Development Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Macromolecule Biosynthetic Process Response To Organic Substance Cellular Metabolic Process Response To Stress Positive Regulation Of Apoptotic Process Response To Steroid Hormone Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Organic Substance Regulation Of Cell Cycle	Protein Localization To Organelle Extrinsic Apoptotic Signaling Pathway Cellular Response To Tumor Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasmic Transport Phosphatidylinositol-mediated Signaling Negative Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Protein Import Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Hypermethylation Of CpG Island Protein Import Into Mitochondrial Outer Membrane Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Abiotic Stimulus Negative Regulation Of Kinase Activity Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Response To Tumor Cell Nucleocytoplasmic Transport Nuclear Transport Fc Receptor Signaling Pathway Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Immune Response Protein Localization To Microtubule Negative Regulation Of Transferase Activity Defense Response Cellular Protein Localization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of Protein Phosphorylation Response To Metal Ion Negative Regulation Of NFAT Protein Import Into Nucleus Protein Transport
Tagcloud ?		aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate	activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate	activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?