TMED2 and COPA

Number of citations of the paper that reports this interaction (PubMedID 8703076)
0

Data Source:
HPRD (in vitro)

		TMED2	COPA
Description		transmembrane p24 trafficking protein 2	coat protein complex I subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Growth Cone COPI-coated Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Frizzled Binding Smoothened Binding Protein Binding	MRNA Binding Hormone Activity Structural Molecule Activity Protein Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Embryonic Placenta Development Maternal Placenta Development Heart Looping Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Inflammatory Response Endoplasmic Reticulum Organization Golgi Organization Intracellular Protein Localization Protein Secretion Positive Regulation Of Gene Expression Protein Transport Vesicle-mediated Transport Somite Rostral/caudal Axis Specification Negative Regulation Of GTPase Activity Multicellular Organism Growth Vesicle Cargo Loading Post-anal Tail Morphogenesis PERK-mediated Unfolded Protein Response Negative Regulation Of Smoothened Signaling Pathway COPI Coating Of Golgi Vesicle COPII Vesicle Coating Embryonic Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development Chorion Development Maintenance Of Protein Localization In Organelle Protein Localization To Plasma Membrane Endoplasmic Reticulum Membrane Organization Negative Regulation Of Protein Localization To Plasma Membrane Allantois Development Regulation Of SREBP Signaling Pathway	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Protein Transport Vesicle-mediated Transport Pancreatic Juice Secretion Protein Localization To Axon Protein Localization To Cell Leading Edge
Pathways		Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Breast size ( 27182965)
Interacting Genes		9 interacting genes: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10	21 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 HUNK MTNR1B PDGFRB PTEN RBM11 RUNX1 SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2
Entrez ID		10959	1314
HPRD ID		17984	03564
Ensembl ID		ENSG00000086598	ENSG00000122218
Uniprot IDs		Q15363 Q6FHT8	P53621
PDB IDs		5AZW	6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Golgi Membrane Cis-Golgi Network Cellular Localization Intracellular Protein Localization Protein Transport Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle-mediated Transport Golgi Vesicle Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Ribbon Formation COPI-coated Vesicle Intracellular Protein Transport Vesicle Cargo Loading Vesicle Budding From Membrane Intracellular Transport COPII-coated ER To Golgi Transport Vesicle Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Syntaxin Binding Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Cellular Response To High Light Intensity Establishment Of Localization In Cell Mitotic Cleavage Furrow Ingression Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Response To High Light Intensity Retinal Rod Cell Apoptotic Process Cleavage Furrow Ingression Transport Vesicle Endoplasmic Reticulum Membrane Positive Regulation Of Cap-dependent Translational Initiation Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Localization To Cell Leading Edge Positive Regulation Of Protein Glycosylation Vesicle Targeting, To, From Or Within Golgi Pancreatic Juice Secretion COPII-coated Vesicle Budding Positive Regulation Of Cytoplasmic Translational Initiation Golgi Disassembly COPI Coating Of Golgi Vesicle Retinal Cell Apoptotic Process Regulation Of Protein Glycosylation Gamma-secretase Complex Membrane	COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Membrane Golgi Vesicle Transport Golgi Apparatus COPI Coating Of Golgi Vesicle Establishment Of Protein Localization Golgi Localization Intracellular Protein Localization Phosphatidylinositol-3-phosphate Phosphatase Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum Membrane Cell Migration Involved In Heart Development Zymogen Granule Membrane Protein Transport Dendritic Spine Morphogenesis Cytoplasmic Vesicle Intracellular Transport Intracellular Protein Transport Golgi Organization Phosphatidylinositol Dephosphorylation COPII Vesicle Coating Vesicle Cargo Loading Dendritic Spine Organization Intra-Golgi Vesicle-mediated Transport Membrane Organization Phospholipid Dephosphorylation COPII-coated ER To Golgi Transport Vesicle Vesicle Coating Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Negative Regulation Of Synaptic Vesicle Clustering Oxoglutarate:malate Antiporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Neuron Projection Organization Postsynapse Organization Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Syntaxin Binding Cerebellar Purkinje Cell Layer Maturation GBD Domain Binding Storage Vacuole
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