TMED2 and TMED10

Number of citations of the paper that reports this interaction (PubMedID 37071682)
87

Data Source:
BioGRID (cross-linking study)
HPRD (in vitro, in vivo)

		TMED2	TMED10
Description		transmembrane p24 trafficking protein 2	transmembrane p24 trafficking protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex
	Molecular Function	Frizzled Binding Smoothened Binding Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Embryonic Placenta Development Maternal Placenta Development Heart Looping Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Inflammatory Response Endoplasmic Reticulum Organization Golgi Organization Intracellular Protein Localization Protein Secretion Positive Regulation Of Gene Expression Protein Transport Vesicle-mediated Transport Somite Rostral/caudal Axis Specification Negative Regulation Of GTPase Activity Multicellular Organism Growth Vesicle Cargo Loading Post-anal Tail Morphogenesis PERK-mediated Unfolded Protein Response Negative Regulation Of Smoothened Signaling Pathway COPI Coating Of Golgi Vesicle COPII Vesicle Coating Embryonic Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development Chorion Development Maintenance Of Protein Localization In Organelle Protein Localization To Plasma Membrane Endoplasmic Reticulum Membrane Organization Negative Regulation Of Protein Localization To Plasma Membrane Allantois Development Regulation Of SREBP Signaling Pathway	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Vesicle-mediated Transport Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation
Pathways		Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10	20 interacting genes: APH1A ARCN1 ARF1 CDC42 CEBPA COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 NCSTN NPSR1 PSENEN SEC23B SLC13A1 TMED2
Entrez ID		10959	10972
HPRD ID		17984	12013
Ensembl ID		ENSG00000086598	ENSG00000170348
Uniprot IDs		Q15363 Q6FHT8	A0A024R6I3 P49755
PDB IDs		5AZW
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Golgi Membrane Cis-Golgi Network Cellular Localization Intracellular Protein Localization Protein Transport Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle-mediated Transport Golgi Vesicle Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Ribbon Formation COPI-coated Vesicle Intracellular Protein Transport Vesicle Cargo Loading Vesicle Budding From Membrane Intracellular Transport COPII-coated ER To Golgi Transport Vesicle Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Syntaxin Binding Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Cellular Response To High Light Intensity Establishment Of Localization In Cell Mitotic Cleavage Furrow Ingression Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Response To High Light Intensity Retinal Rod Cell Apoptotic Process Cleavage Furrow Ingression Transport Vesicle Endoplasmic Reticulum Membrane Positive Regulation Of Cap-dependent Translational Initiation Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Localization To Cell Leading Edge Positive Regulation Of Protein Glycosylation Vesicle Targeting, To, From Or Within Golgi Pancreatic Juice Secretion COPII-coated Vesicle Budding Positive Regulation Of Cytoplasmic Translational Initiation Golgi Disassembly COPI Coating Of Golgi Vesicle Retinal Cell Apoptotic Process Regulation Of Protein Glycosylation Gamma-secretase Complex Membrane	COPI-coated Vesicle Membrane COPI Vesicle Coat Golgi Membrane Transport Vesicle COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Membrane Coat Endoplasmic Reticulum Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Transport Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Protein Transport Gamma-secretase Complex Structural Molecule Activity Notch Receptor Processing Amyloid-beta Formation Intracellular Protein Localization Membrane Protein Intracellular Domain Proteolysis Golgi Localization Amyloid Precursor Protein Catabolic Process Endopeptidase Activator Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Membrane Membrane Protein Proteolysis Notch Signaling Pathway Establishment Of Golgi Localization Endoplasmic Reticulum Golgi Cisterna Membrane Protein Localization To Axon Organelle Transport Along Microtubule Embryonic Placenta Development Protein Secretion Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Presynaptic Membrane Vesicle Cargo Loading Dendritic Spine Organization Mitotic Cleavage Furrow Ingression RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
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