TMED2 and AKT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMED2	AKT2
Description		transmembrane p24 trafficking protein 2	AKT serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane
	Molecular Function	Frizzled Binding Smoothened Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Embryonic Placenta Development Maternal Placenta Development Heart Looping Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Inflammatory Response Endoplasmic Reticulum Organization Golgi Organization Intracellular Protein Localization Protein Secretion Positive Regulation Of Gene Expression Protein Transport Vesicle-mediated Transport Somite Rostral/caudal Axis Specification Negative Regulation Of GTPase Activity Multicellular Organism Growth Vesicle Cargo Loading Post-anal Tail Morphogenesis PERK-mediated Unfolded Protein Response Negative Regulation Of Smoothened Signaling Pathway COPI Coating Of Golgi Vesicle COPII Vesicle Coating Embryonic Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development Chorion Development Maintenance Of Protein Localization In Organelle Protein Localization To Plasma Membrane Endoplasmic Reticulum Membrane Organization Negative Regulation Of Protein Localization To Plasma Membrane Allantois Development Regulation Of SREBP Signaling Pathway	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility
Pathways		Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation
Drugs			N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases			Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS		Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)
Interacting Genes		9 interacting genes: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10	43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		10959	208
HPRD ID		17984	01262
Ensembl ID		ENSG00000086598	ENSG00000105221
Uniprot IDs		Q15363 Q6FHT8	B4DG79 P31751
PDB IDs		5AZW	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Golgi Membrane Cis-Golgi Network Cellular Localization Intracellular Protein Localization Protein Transport Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle-mediated Transport Golgi Vesicle Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Ribbon Formation COPI-coated Vesicle Intracellular Protein Transport Vesicle Cargo Loading Vesicle Budding From Membrane Intracellular Transport COPII-coated ER To Golgi Transport Vesicle Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Syntaxin Binding Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Cellular Response To High Light Intensity Establishment Of Localization In Cell Mitotic Cleavage Furrow Ingression Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Response To High Light Intensity Retinal Rod Cell Apoptotic Process Cleavage Furrow Ingression Transport Vesicle Endoplasmic Reticulum Membrane Positive Regulation Of Cap-dependent Translational Initiation Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Localization To Cell Leading Edge Positive Regulation Of Protein Glycosylation Vesicle Targeting, To, From Or Within Golgi Pancreatic Juice Secretion COPII-coated Vesicle Budding Positive Regulation Of Cytoplasmic Translational Initiation Golgi Disassembly COPI Coating Of Golgi Vesicle Retinal Cell Apoptotic Process Regulation Of Protein Glycosylation Gamma-secretase Complex Membrane	Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response
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