YJU2 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YJU2	TRIM21
Description		YJU2 splicing factor homolog	tripartite motif containing 21
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 1 Spliceosome	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Protein Binding Metal Ion Binding	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		mRNA Splicing - Major Pathway	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		22 interacting genes: BANP BRAP CCDC57 CEP70 DRC4 EMILIN1 FRS2 GOLGA2 GOLGA6A JADE1 KAT5 LNX2 MAD1L1 MEOX2 REL TFCP2 TRIM15 TRIM21 TRIM27 ZNF143 ZNF526 ZNF829	86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		55702	6737
HPRD ID		08546	00170
Ensembl ID		ENSG00000105248	ENSG00000132109
Uniprot IDs		Q9BW85	P19474
PDB IDs		5YZG 6ZYM 7A5P 8I0W	2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		Suppression Of Viral Release By Host Regulation Of Type I Interferon Production Canonical NF-kappaB Signal Transduction Zinc Ion Binding Transcription Coactivator Activity Positive Regulation Of Mitotic Sister Chromatid Segregation Histone H4K16 Acetyltransferase Activity Golgi Cis Cisterna Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Organelle Disassembly Regulation Of Metaphase Plate Congression Positive Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of Viral Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Ubiquitin-protein Transferase Activity Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Microtubule Nucleation DNA Binding Regulation Of Viral Process Positive Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Spindle Pole Ubiquitin Protein Ligase Activity Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Regulation Of Autophagy Innate Immune Response MAD1 Complex Histone H2AK5 Acetyltransferase Activity Regulation Of Protein Binding Positive Regulation Of Autophagy Negative Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Cytoskeleton Cis-Golgi Network Organelle Assembly DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Microtubule Cytoskeleton Organization Defense Response To Other Organism Defense Response To Symbiont	Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy
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