PCMTD2 and PIGP

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCMTD2	PIGP
Description		protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	phosphatidylinositol glycan anchor biosynthesis class P
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process		GPI Anchor Biosynthetic Process
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Clozapine-induced cytotoxicity ( 25656473) Coffee consumption ( 31046077) Estimated glomerular filtration rate ( 31152163) LDL cholesterol levels ( 32203549)
Interacting Genes		5 interacting genes: ACSL6 ATP13A2 PIGP TRIP13 VAC14	23 interacting genes: C1GALT1 CLK1 CNST DHRSX FIS1 IER3IP1 ITGAM LHFPL3 NABP2 NINJ2 PCMTD2 PLP1 PLP2 PTPN1 SCAMP5 SMAGP SNRNP70 THSD7B TMEM107 TMEM168 TMEM19 TMEM229B UBIAD1
Entrez ID		55251	51227
HPRD ID		12764	05806
Ensembl ID		ENSG00000203880	ENSG00000185808
Uniprot IDs		Q9NV79	P57054
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Biosynthetic Process Organophosphate Biosynthetic Process Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity PAS Complex Phosphatidylinositol Biosynthetic Process Meiotic Recombination Checkpoint Signaling Organophosphate Metabolic Process Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Late Endosome Membrane Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Cupric Ion Binding Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Phosphatidylinositol Metabolic Process Female Meiosis I Meiotic Cell Cycle Checkpoint Signaling Lipid Metabolic Process Regulation Of Chaperone-mediated Autophagy Polyamine Transmembrane Transport Glycerophospholipid Metabolic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Presynaptic Endosome Negative Regulation Of Meiotic Nuclear Division Cellular Response To Manganese Ion Arachidonate-CoA Ligase Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process ATP Hydrolysis Activity Long-chain Fatty Acid-CoA Ligase Activity Phosphate-containing Compound Metabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion ATP Binding Negative Regulation Of Meiotic Cell Cycle Female Meiotic Nuclear Division Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Exosomal Secretion Synaptonemal Complex Assembly Endoplasmic Reticulum
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