DIAPH1 and APBB1

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		DIAPH1	APBB1
Gene Name		diaphanous-related formin 1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Ruffle Membrane Neuron Projection Mitotic Spindle	Nucleus Cytoplasm Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	Actin Binding Receptor Binding Protein Binding Profilin Binding Rho GTPase Binding Identical Protein Binding Ion Channel Binding Poly(A) RNA Binding	Beta-amyloid Binding Chromatin Binding Protein Binding Transcription Factor Binding Histone Binding Proline-rich Region Binding
	Biological Process	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Filament Polymerization Positive Regulation Of Cell Migration Neuron Projection Development Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Histamine	Neuron Migration Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Axon Guidance Visual Learning Extracellular Matrix Organization Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A RAC1 RHOA RHOC TCERG1 WBP4 XPO6	66 interactors: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		1729	322
HPRD ID		03670	04087
Ensembl ID		ENSG00000131504	ENSG00000166313
Uniprot IDs		O60610 Q6URC4	O00213
PDB IDs			2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Neuron Projection Development Cell Cycle Regulation Of Cellular Component Organization Neuron Development Neuron Projection Morphogenesis Cell Cycle Process Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Cell Projection Morphogenesis Skeletal Muscle Satellite Cell Migration Cell Part Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Cell Morphogenesis Positive Regulation Of DNA Metabolic Process Nervous System Development Regulation Of Cell Shape Neurogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Anatomical Structure Morphogenesis Cell Development Locomotion Cell Migration Cell Motility Regulation Of Cell Cycle Chemotaxis Organelle Organization Mitotic Cell Cycle Process Response To External Stimulus Response To Stress Mitotic Cell Cycle Protein Localization Cell Cycle Arrest Positive Regulation Of Intracellular Signal Transduction Cellular Protein Localization Cell Division Regulation Of Cell Development Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Cycle Process Negative Regulation Of Neuron Differentiation Wound Healing, Spreading Of Cells	RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Actin Polymerization Or Depolymerization RNA Biosynthetic Process MRNA 3'-splice Site Recognition Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Phagocytosis MRNA 3'-end Processing Cellular Process Regulation Of Metabolic Process Endocytosis Innate Immune Response Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Splicing RNA 3'-end Processing Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Developmental Process Actin Filament-based Process MRNA Stabilization Axon Guidance Positive Regulation Of Actin Nucleation MRNA Polyadenylation
Tagcloud ?		5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?		5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?