DIAPH1 and GAS7

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		DIAPH1	GAS7
Gene Name		diaphanous-related formin 1	growth arrest-specific 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Ruffle Membrane Neuron Projection Mitotic Spindle	Ruffle Cytoplasm Actin Filament
	Molecular Function	Actin Binding Receptor Binding Protein Binding Profilin Binding Rho GTPase Binding Identical Protein Binding Ion Channel Binding Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Actin Filament Binding
	Biological Process	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Filament Polymerization Positive Regulation Of Cell Migration Neuron Projection Development Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Histamine	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Regulation Of Cell Shape Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Intraocular pressure ( 22570627)
Protein-Protein Interactions		15 interactors: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A RAC1 RHOA RHOC TCERG1 WBP4 XPO6	22 interactors: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH HNRNPU KHDRBS1 NCKAP1 NCKAP1L PACSIN1 RPLP0 SF1 SF3A1 SFPQ WAS WASF2 WDYHV1
Entrez ID		1729	8522
HPRD ID		03670	16011
Ensembl ID		ENSG00000131504	ENSG00000007237
Uniprot IDs		O60610 Q6URC4	B7Z1Q2 O60861
PDB IDs			2LX7 2YSH
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Neuron Projection Development Cell Cycle Regulation Of Cellular Component Organization Neuron Development Neuron Projection Morphogenesis Cell Cycle Process Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Cell Projection Morphogenesis Skeletal Muscle Satellite Cell Migration Cell Part Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Cell Morphogenesis Positive Regulation Of DNA Metabolic Process Nervous System Development Regulation Of Cell Shape Neurogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Anatomical Structure Morphogenesis Cell Development Locomotion Cell Migration Cell Motility Regulation Of Cell Cycle Chemotaxis Organelle Organization Mitotic Cell Cycle Process Response To External Stimulus Response To Stress Mitotic Cell Cycle Protein Localization Cell Cycle Arrest Positive Regulation Of Intracellular Signal Transduction Cellular Protein Localization Cell Division Regulation Of Cell Development Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Cycle Process Negative Regulation Of Neuron Differentiation Wound Healing, Spreading Of Cells	Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Nucleation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Actin Filament Organization MRNA Metabolic Process Lamellipodium Morphogenesis MRNA 3'-splice Site Recognition Positive Regulation Of Immune System Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Endocytosis Cellular Component Assembly Actin Filament-based Movement Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Organelle Organization MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization Innate Immune Response Regulation Of Cytoskeleton Organization Cellular Response To Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Immune Response Megakaryocyte Development Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization RNA Processing Regulation Of Cellular Component Organization Vesicle-mediated Transport Megakaryocyte Differentiation Regulation Of Lamellipodium Assembly Movement Of Cell Or Subcellular Component
Tagcloud ?		5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?		5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?