DIAPH1 and XPO6

Number of citations of the paper that reports this interaction (PubMedID 14592989)
61

Data Source:
HPRD (in vitro)

		DIAPH1	XPO6
Description		diaphanous related formin 1	exportin 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Secretory Granule Membrane Ruffle Membrane Cell Projection Mitotic Spindle Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Small GTPase Binding Transmembrane Transporter Binding	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine	Protein Export From Nucleus Intracellular Protein Transport Protein Transport
Pathways		RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOD GTPase cycle RHOF GTPase cycle Regulation of MITF-M dependent genes involved in invasion
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29083406) Femur bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Apolipoprotein A1 levels ( 32203549) Monocyte count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		18 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA EGFR GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6	7 interacting genes: ACTB DIAPH1 NUP62 PFN1 RNF10 SMAD3 VASP
Entrez ID		1729	23214
HPRD ID		03670	10525
Ensembl ID		ENSG00000131504	ENSG00000169180
Uniprot IDs		A0A2R8Y5N1 O60610 Q6URC4	Q96QU8
PDB IDs		8FG1
Enriched GO Terms of Interacting Partners?		Proline-rich Region Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Skeletal Muscle Satellite Cell Migration Lamellipodium Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Cerebral Cortex Cell Migration Cell Motility Regulation Of Cell Cycle Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Regulation Of Actin Filament Organization Neuron Projection Development Telencephalon Cell Migration Regulation Of Synapse Organization Forebrain Cell Migration Membrane Invagination Plasma Membrane Bounded Cell Projection Organization Non-canonical Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Cell Division Cell-cell Junction Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Mitotic Cytokinesis Thioesterase Binding Salivary Gland Morphogenesis Positive Regulation Of Protein-containing Complex Assembly G Protein Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Projection Development Protein Kinase Binding Postsynapse Cell Junction Organization Regulation Of Cytokinesis	Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Cytoskeleton Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Actin Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Lung Blood Pressure Regulation Of Supramolecular Fiber Organization Nuclear Mineralocorticoid Receptor Binding Regulation Of Actin Filament-based Process Focal Adhesion Actin Filament Positive Regulation Of Protein Polymerization Neural Tube Closure Positive Regulation Of Cellular Component Organization Tube Closure Cell Junction Organization Regulation Of Stress Fiber Assembly Ubiquitin Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Transforming Growth Factor Beta3 Production Blood Microparticle Regulation Of Actin Filament Polymerization Transporter Regulator Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Tube Formation PTB Domain Binding Mitotic Spindle Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Transepithelial Transport Regulation Of Lung Blood Pressure Cytoplasm Negative Regulation Of Cell Differentiation
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