DIAPH1 and TCERG1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		DIAPH1	TCERG1
Description		diaphanous related formin 1	transcription elongation regulator 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Secretory Granule Membrane Ruffle Membrane Cell Projection Mitotic Spindle Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Small GTPase Binding Transmembrane Transporter Binding	Transcription Elongation Factor Activity Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase Binding
	Biological Process	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOD GTPase cycle RHOF GTPase cycle Regulation of MITF-M dependent genes involved in invasion	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29083406) Femur bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		18 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA EGFR GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6	56 interacting genes: ABI1 AURKA BARD1 CEBPA CHAF1A CHD3 CYFIP1 CYFIP2 DIAPH1 DIAPH2 DNAJB9 ESR1 EVL FANCA FANCC FMNL1 GRB2 HNRNPH1 HNRNPK HNRNPM HNRNPU HSPA1A HSPA5 HSPA8 HTT JUNB LUC7L NONO NPM1 NUDT21 PCBP1 PIAS4 POLR2A PSPC1 RNF10 RUNX1 SETDB1 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SRSF1 SUMO2 TPM4 U2AF2 UBE2I WAS WASF2 WBP4 WIPF2 WWOX
Entrez ID		1729	10915
HPRD ID		03670	10393
Ensembl ID		ENSG00000131504	ENSG00000113649
Uniprot IDs		A0A2R8Y5N1 O60610 Q6URC4	A0A7P0T8N8 O14776
PDB IDs		8FG1	2DK7 2DOD 2DOE 2DOF 2E71 2KIQ 2KIS 2MW9 2MWA 2MWB 2MWD 2MWE 2MWF 2N4R 2N4S 2N4T 2N4U 2N4V 2N4W 2NNT 3HFH 3Q1I 4FQG 7ABF 7ABG 8Q7N 8QO9
Enriched GO Terms of Interacting Partners?		Proline-rich Region Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Skeletal Muscle Satellite Cell Migration Lamellipodium Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Cerebral Cortex Cell Migration Cell Motility Regulation Of Cell Cycle Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Regulation Of Actin Filament Organization Neuron Projection Development Telencephalon Cell Migration Regulation Of Synapse Organization Forebrain Cell Migration Membrane Invagination Plasma Membrane Bounded Cell Projection Organization Non-canonical Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Cell Division Cell-cell Junction Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Mitotic Cytokinesis Thioesterase Binding Salivary Gland Morphogenesis Positive Regulation Of Protein-containing Complex Assembly G Protein Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Projection Development Protein Kinase Binding Postsynapse Cell Junction Organization Regulation Of Cytokinesis	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process RNA Binding Catalytic Step 2 Spliceosome Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Nuclear Speck Nucleoplasm U2-type Prespliceosome Assembly Nucleus Nucleic Acid Binding U2 SnRNP RNA Metabolic Process Nucleobase-containing Compound Metabolic Process U2-type Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Processing Protein-containing Complex Assembly Protein-containing Complex Organization Protein-RNA Complex Assembly Paraspeckles Cellular Component Assembly MRNA Splice Site Recognition MRNA 3'-splice Site Recognition U2-type Prespliceosome Regulation Of RNA Splicing SCAR Complex Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Matrix Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Actin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Actin Polymerization Or Depolymerization Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex MRNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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