CDX4 and HOXA5

Number of citations of the paper that reports this interaction (PubMedID 15684390)
65

Data Source:
HPRD (in vitro, in vivo)

		CDX4	HOXA5
Description		caudal type homeobox 4	homeobox A5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Labyrinthine Layer Development	Skeletal System Development Morphogenesis Of An Epithelium Respiratory System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Respiratory Gaseous Exchange By Respiratory System Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Migration Negative Regulation Of Angiogenesis Lung Development Thyroid Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Bronchiole Development Trachea Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Goblet Cell Differentiation Lobar Bronchus Epithelium Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Cartilage Morphogenesis Intestinal Epithelial Cell Maturation Mesenchymal-epithelial Cell Signaling Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cell-cell Signaling Involved In Mammary Gland Development
Pathways
Drugs
Diseases
GWAS			Chronic venous disease ( 28374850)
Interacting Genes		9 interacting genes: BANP CKS1B HOXA5 LMO1 LMO2 PITX1 PRKAA1 PRKAA2 PRKAB2	16 interacting genes: CDX4 CTBP2 DDIT3 DNMT3L DVL3 FOXA2 FOXO1 GTF2A1L MEIS1 PBX1 PBX2 PICK1 PRMT6 SMAD1 TWIST1 ZNF408
Entrez ID		1046	3202
HPRD ID		02065	00840
Ensembl ID		ENSG00000131264	ENSG00000106004
Uniprot IDs		O14627	P20719
PDB IDs
Enriched GO Terms of Interacting Partners?		AMP-activated Protein Kinase Activity Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Lipid Droplet Negative Regulation Of Tubulin Deacetylation Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Fatty Acid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Cellular Response To Prostaglandin E Stimulus Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process Lipid Droplet Organization Sterol Biosynthetic Process Regulation Of Release Of Cytochrome C From Mitochondria Epithelial Cell Apoptotic Process Negative Regulation Of Translational Initiation Carboxylic Acid Biosynthetic Process Cellular Response To Nutrient Levels Positive Regulation Of Translational Initiation Cellular Response To Glucose Starvation Positive Regulation Of Metabolic Process Regulation Of Glycolytic Process Regulation Of Epithelial Cell Apoptotic Process Protein Localization To Lysosome Fatty Acid Metabolic Process Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Cellular Response To Xenobiotic Stimulus Negative Regulation Of Glucosylceramide Biosynthetic Process Cellular Response To Glucose Stimulus Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Phosphatidylcholine Metabolic Process	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Negative Regulation Of Cell Differentiation Regulation Of Metabolic Process Transcription Regulator Complex Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Embryonic Pattern Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleus Sequence-specific DNA Binding Embryonic Limb Morphogenesis Regulation Of Developmental Process Limb Morphogenesis Stem Cell Differentiation Animal Organ Development Eye Development Developmental Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Proximal/distal Pattern Formation
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