BTBD2 and TOP1

Number of citations of the paper that reports this interaction (PMID 11818025)
7

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		BTBD2	TOP1
Gene Name		BTB (POZ) domain containing 2	topoisomerase (DNA) I
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon
	Molecular Function	Protein Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding
	Biological Process		DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug
Pathways
Drugs			Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		26 interactors: BRD7 C14orf1 CCDC90B CDK2 COPS6 CRMP1 DPPA4 EEF1A1 GAPDH GBP2 GDF9 IGSF21 KPNA2 PTN RBM48 SETDB1 SMAD1 SMAD2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B	55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I
Entrez ID		55643	7150
HPRD ID		12252	00535
Ensembl ID		ENSG00000133243	ENSG00000198900
Uniprot IDs		Q9BX70	P11387
PDB IDs		3NO8	1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Primary MiRNA Processing Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Stimulus Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway SMAD Protein Complex Assembly Nucleobase-containing Compound Metabolic Process Growth Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Viral Process Cell Fate Commitment Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Response To Cholesterol Macromolecule Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Activin Receptor Signaling Pathway	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated
Tagcloud ?			anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Difference) ?			anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Intersection) ?