BTBD2 and ZYG11B

Data Source: HiPPIP (Novel)

		BTBD2	ZYG11B
Name		BTB domain containing 2	zyg-11 family member B, cell cycle regulator
Structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol	Cytoplasm Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Neurogenesis	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
GWAS		Mitochondrial DNA copy number (white blood cells) ( 30704525 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 )	Monocyte percentage of white cells ( 32888494 )
Novel Interactors		1 novel interactors: ZYG11B	10 novel interactors: ARPC2 ASPA BTBD2 BTF3L4 CFL2 NDC1 OSBPL9 SH2D2A TLR6 UCK2
Interacting Genes		37 interacting genes: BRD7 CCDC90B CCNC CDK2 CINP COPS6 CRMP1 CUL3 DPPA4 EEF1A1 ERG28 FXR1 GAPDH GBP2 GDF9 IGSF21 KPNA2 MLH1 NGB NTAQ1 OSGIN1 PSMD5 PTN RBM48 RUNX1 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B	4 interacting genes: CUL2 ELOB ELOC GBF1
Entrez ID		55643	79699
HPRD ID		12252	13356
Ensembl ID		ENSG00000133243	ENSG00000162378
Uniprot IDs		Q9BX70	A8DPD7 B4DK95 Q9C0D3
PDB IDs		3NO8	7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2
GO Terms Enriched among Interactors		Male Germ Cell Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Homomeric SMAD Protein Complex Positive Regulation Of Gene Expression Disordered Domain Specific Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Nucleoplasm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Trophoblast Cell Migration Peptidyl-serine Phosphorylation Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Gastrulation Embryonic Cleavage Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process DNA-templated Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Female Gamete Generation Primary MiRNA Processing Co-SMAD Binding Mesenchyme Development Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neuroblast Proliferation Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Dendrite Development Ubiquitin Protein Ligase Binding Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Mitotic G1/S Transition Checkpoint Signaling Regulation Of MiRNA Transcription Cell Fate Commitment Negative Regulation Of RNA Metabolic Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of MiRNA Metabolic Process	Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway