PRKAA1 and CTBP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKAA1	CTBP1
Gene Name		protein kinase, AMP-activated, alpha 1 catalytic subunit	C-terminal binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Transcriptional Repressor Complex
	Molecular Function	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Protein Homodimerization Activity NAD Binding Repressing Transcription Factor Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Phosphorylation Golgi Organization Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Pathways		Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs		Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS		Gastric cancer ( 22037551)
Protein-Protein Interactions		58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1	83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FOXP1 FOXP2 FUNDC1 GTF2B HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HIST3H3 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCOR LCORL LNX1 MAPK9 MARCH10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 ORC4 PIAS2 PLCB1 PNN PRKAA1 RAI2 RB1 RBBP5 RBBP8 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TCF7L2 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		5562	1487
HPRD ID		04115	04015
Ensembl ID		ENSG00000132356	ENSG00000159692
Uniprot IDs		Q13131	Q13363
PDB IDs			1MX3
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Chromosome Organization Positive Regulation Of Metabolic Process Developmental Process Chromatin Modification Embryo Development Transcription From RNA Polymerase II Promoter Anatomical Structure Development Chromatin Organization Histone H4 Deacetylation Regulation Of Cell Differentiation Organelle Organization Organ Development Metabolic Process Regulation Of Cellular Process System Development
Tagcloud ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Difference) ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Intersection) ?