PRKAA1 and DVL2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		PRKAA1	DVL2
Description		protein kinase AMP-activated catalytic subunit alpha 1	dishevelled segment polarity protein 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Protein-containing Complex Ciliary Basal Body Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Lateral Plasma Membrane Nuclear Body Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Response To Hypoxia Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Glucose Metabolic Process Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Lysosome Organization Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Sterol Biosynthetic Process Fatty Acid Oxidation Response To Caffeine SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Stress Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Protein Localization To Lysosome Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Adipose Tissue Development Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet	Neural Tube Closure Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Segment Specification Heart Development Intracellular Protein Localization Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Regulation Of Actin Cytoskeleton Organization Segmentation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs		Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib
Diseases
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26129866 26701879)	Metabolite levels ( 31628463)
Interacting Genes		72 interacting genes: ABI2 ACACA AGAP2 ATM BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MAGEA3 MAGEA6 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SLC31A1 SRPK2 SSX2IP THAP1 TLE5 TOMM34 TRIM27 TRIM28 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	105 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 AQP9 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 CUL1 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RAP1B RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 WWP2 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581
Entrez ID		5562	1856
HPRD ID		04115	03690
Ensembl ID		ENSG00000132356	ENSG00000004975
Uniprot IDs		Q13131	O14641
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74	2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK 8WM9 8WMA 8WWR 8YR7
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Regulation Of Macromolecule Metabolic Process Nucleotide-activated Protein Kinase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Autophagy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleoplasm Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Protein Phosphorylation Cytoplasm Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Autophagy Negative Regulation Of Catabolic Process Response To Starvation Protein Binding Protein Modification Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Cycle Cation Binding Response To Nutrient Levels Protein Serine/threonine Phosphatase Activity Negative Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process	Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Wnt Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytosol Protein Modification By Small Protein Conjugation Protein Ubiquitination Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Protein Modification Process Nucleoplasm Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Protein Modification Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Cytoskeleton Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Autophagy
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