PRKAA1 and CDX4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKAA1	CDX4
Gene Name		protein kinase, AMP-activated, alpha 1 catalytic subunit	caudal type homeobox 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex	Nucleus
	Molecular Function	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Transcription, DNA-templated Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Development
Pathways		Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs		Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS		Gastric cancer ( 22037551)
Protein-Protein Interactions		58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1	7 interactors: CKS1B HOXA5 LMO1 LMO2 PITX1 PRKAA1 PRKAB2
Entrez ID		5562	1046
HPRD ID		04115	02065
Ensembl ID		ENSG00000132356
Uniprot IDs		Q13131	O14627
PDB IDs
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation	Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Gene Expression Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Negative Regulation Of Glucose Import In Response To Insulin Stimulus Cell-cell Signaling Involved In Mammary Gland Development Branchiomeric Skeletal Muscle Development Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Camptothecin Bronchiole Development Lung Goblet Cell Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Kinase Activity Cartilage Development Intestinal Epithelial Cell Maturation Transcription From RNA Polymerase II Promoter Cellular Response To Insulin Stimulus Negative Regulation Of Sphingolipid Biosynthetic Process Lobar Bronchus Development Myoblast Fate Commitment Regulation Of Cell Cycle Response To Hormone Connective Tissue Development Regulation Of Ceramide Biosynthetic Process Transcription, DNA-templated Carnitine Shuttle Positive Regulation Of Cholesterol Biosynthetic Process Cell Cycle Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Bronchus Development Trachea Cartilage Morphogenesis Regulation Of Protein Phosphorylation RNA Biosynthetic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	alters auto caudal chip circuit coregulate deeper defects erythroid erythropoiesis explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 seq spalt zebrafish
Tagcloud (Difference) ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	alters auto caudal chip circuit coregulate deeper defects erythroid erythropoiesis explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 seq spalt zebrafish
Tagcloud (Intersection) ?