PRKAA1 and GRIK2

Number of citations of the paper that reports this interaction (PubMedID 8163463)
0

Data Source:
HPRD (in vivo)

		PRKAA1	GRIK2
Description		protein kinase AMP-activated catalytic subunit alpha 1	glutamate ionotropic receptor kainate type subunit 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Protein-containing Complex Ciliary Basal Body Neuronal Cell Body	Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Neuronal Cell Body Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Mossy Fiber Rosette Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity	SNARE Binding Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Autophagosome Assembly Response To Hypoxia Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Glucose Metabolic Process Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Lysosome Organization Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Sterol Biosynthetic Process Fatty Acid Oxidation Response To Caffeine SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Stress Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Protein Localization To Lysosome Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Adipose Tissue Development Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet	Behavioral Fear Response Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib	Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26129866 26701879)	A body shape index ( 34021172) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196)
Interacting Genes		72 interacting genes: ABI2 ACACA AGAP2 ATM BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MAGEA3 MAGEA6 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SLC31A1 SRPK2 SSX2IP THAP1 TLE5 TOMM34 TRIM27 TRIM28 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	20 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK1 GRIK4 GRIK5 GRIP1 LIN7B NETO1 PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		5562	2898
HPRD ID		04115	00692
Ensembl ID		ENSG00000132356	ENSG00000164418
Uniprot IDs		Q13131	A0A8D9PH75 A8K0H7 Q13002 Q8IY40
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74	3QXM 5CMM
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Regulation Of Macromolecule Metabolic Process Nucleotide-activated Protein Kinase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Autophagy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleoplasm Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Protein Phosphorylation Cytoplasm Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Autophagy Negative Regulation Of Catabolic Process Response To Starvation Protein Binding Protein Modification Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Cycle Cation Binding Response To Nutrient Levels Protein Serine/threonine Phosphatase Activity Negative Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process	Postsynaptic Density Membrane Synapse Postsynaptic Membrane Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Cell-cell Junction Presynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Cell-cell Signaling Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Cell Communication Adherens Junction Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Membrane Potential AMPA Glutamate Receptor Complex Protein Localization To Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Plasma Membrane Localization Within Membrane Neuron Projection Intracellular Protein Localization Regulation Of Postsynaptic Membrane Potential Glutamate-gated Receptor Activity Basolateral Plasma Membrane Regulation Of Transport Postsynaptic Density Phosphatase Binding Regulation Of Biological Quality Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Cell-cell Adhesion Protein-containing Complex Localization Monoatomic Ion Channel Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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