PRKAA1 and PRKAG3

Number of citations of the paper that reports this interaction (PubMedID 8626596)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PRKAA1	PRKAG3
Description		protein kinase AMP-activated catalytic subunit alpha 1	protein kinase AMP-activated non-catalytic subunit gamma 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Protein-containing Complex Ciliary Basal Body Neuronal Cell Body	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity	Nucleotide Binding AMP-activated Protein Kinase Activity Protein Binding ATP Binding AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Autophagosome Assembly Response To Hypoxia Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Glucose Metabolic Process Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Lysosome Organization Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Sterol Biosynthetic Process Fatty Acid Oxidation Response To Caffeine SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Stress Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Protein Localization To Lysosome Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Adipose Tissue Development Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet	Regulation Of Glycolytic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Nutrient Levels Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Gluconeogenesis Regulation Of Cell Cycle
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26129866 26701879)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol ( 25961943) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Triglyceride levels ( 32203549 33339817)
Interacting Genes		72 interacting genes: ABI2 ACACA AGAP2 ATM BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MAGEA3 MAGEA6 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SLC31A1 SRPK2 SSX2IP THAP1 TLE5 TOMM34 TRIM27 TRIM28 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	6 interacting genes: BRCA1 CRYAB KRTAP19-5 LMCD1 NGRN PRKAA1
Entrez ID		5562	53632
HPRD ID		04115	16085
Ensembl ID		ENSG00000132356	ENSG00000115592
Uniprot IDs		Q13131	Q9UGI9
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Regulation Of Macromolecule Metabolic Process Nucleotide-activated Protein Kinase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Autophagy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleoplasm Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Protein Phosphorylation Cytoplasm Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Autophagy Negative Regulation Of Catabolic Process Response To Starvation Protein Binding Protein Modification Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Cycle Cation Binding Response To Nutrient Levels Protein Serine/threonine Phosphatase Activity Negative Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process	Response To Ionizing Radiation Protein K6-linked Ubiquitination Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Gamma Radiation Negative Regulation Of Lipid Biosynthetic Process Response To Radiation Cellular Response To Ionizing Radiation Negative Regulation Of Glucosylceramide Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Response To Hydrogen Peroxide Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process BRCA1-B Complex Negative Regulation Of Cell Growth Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Cellular Response To Radiation Protein-containing Complex Response To Indole-3-methanol Regulation Of Lipid Biosynthetic Process Response To Reactive Oxygen Species Response To Temperature Stimulus Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Cold Acclimation Positive Regulation Of Mitochondrial Transcription Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Positive Regulation Of Translation Protein Localization To Lipid Droplet CAMKK-AMPK Signaling Cascade Mitochondrial Ribosome Assembly Negative Regulation Of Centriole Replication Negative Regulation Of Growth Negative Regulation Of Apoptotic Process Cardiac Myofibril Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of Programmed Cell Death BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Protein Stabilization
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