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PRKAA1 and PRKAB1
Number of citations of the paper that reports this interaction (PubMedID
8663446
)
0
Data Source:
HPRD
(two hybrid, in vitro)
PRKAA1
PRKAB1
Description
protein kinase AMP-activated catalytic subunit alpha 1
protein kinase AMP-activated non-catalytic subunit beta 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cilium
Apical Plasma Membrane
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Ciliary Basal Body
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Molecular Function
Nucleotide Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein-containing Complex Binding
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Histone H2BS36 Kinase Activity
Protein Binding
Protein Kinase Binding
Biological Process
Autophagosome Assembly
Response To Hypoxia
Cytoplasmic Translation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glucose Metabolic Process
Chromatin Organization
Chromatin Remodeling
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Phosphatidylethanolamine Biosynthetic Process
Phosphatidylcholine Biosynthetic Process
Steroid Biosynthetic Process
Cholesterol Biosynthetic Process
Autophagy
Lysosome Organization
Signal Transduction
Steroid Metabolic Process
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Xenobiotic Stimulus
Response To UV
Cold Acclimation
Response To Gamma Radiation
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Activity
Wnt Signaling Pathway
Sterol Biosynthetic Process
Fatty Acid Oxidation
Response To Caffeine
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
TORC1 Signaling
Cellular Response To Glucose Starvation
Response To Hydrogen Peroxide
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Estrogen
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Glucosylceramide Biosynthetic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Rhythmic Process
Positive Regulation Of Skeletal Muscle Tissue Development
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Negative Regulation Of Lipid Catabolic Process
Fatty Acid Homeostasis
Regulation Of Vesicle-mediated Transport
Protein Localization To Lysosome
Motor Behavior
CAMKK-AMPK Signaling Cascade
Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Neuron Cellular Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Ethanol
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Protein K6-linked Ubiquitination
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Energy Homeostasis
Hepatocyte Apoptotic Process
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Mitochondrial Transcription
Positive Regulation Of Protein Localization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Protein Localization To Lipid Droplet
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Signal Transduction
Cellular Response To Nutrient Levels
Nail Development
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Adenosine phosphate
Adenosine phosphate
ATP
Phenformin
Acetylsalicylic acid
Fostamatinib
Fostamatinib
Adenosine phosphate
Adenosine phosphate
Metformin
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Cardia gastric cancer (
26129866
)
Gastric cancer (
22037551
26098866
26129866
31383772
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Non-cardia gastric cancer (
26129866
26701879
)
Basophil count (
32888494
)
Inflammatory bowel disease (
26192919
)
Lymphocyte percentage of white cells (
32888494
)
Mitochondrial heteroplasmy measurement (
33731350
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
Plateletcrit (
32888494
)
Ulcerative colitis (
26192919
)
White blood cell count (
32888494
)
Interacting Genes
72 interacting genes:
ABI2
ACACA
AGAP2
ATM
BHLHE40
CAB39
CAMKK1
CDX4
CFTR
CHEK1
CRTC2
CTBP1
DVL2
EEF2K
EPM2A
FANCA
FNIP1
GATA1
GOLGA2
GRIK2
HDAC5
HMBOX1
HOMEZ
IKZF3
INO80E
KIF16B
KRT40
L3MBTL3
MAGEA3
MAGEA6
MDM4
MORC4
MTOR
MTUS2
PASK
PFKFB2
PHC2
PNMA5
PPM1A
PPM1E
PPM1F
PPP2CA
PRKAB1
PRKAB2
PRKAG1
PRKAG3
PSMD11
RACK1
RAD54B
RAF1
RBPMS
RFX6
RIMBP3
ROPN1
RPTOR
SLC31A1
SRPK2
SSX2IP
THAP1
TLE5
TOMM34
TRIM27
TRIM28
TRIP6
TSC2
TSC22D4
TXNIP
UBXN11
ULK1
VPS37B
VPS52
ZBED1
13 interacting genes:
ACACA
AGL
APP
F10
GRB2
MAP3K7
MAPK6
NDUFA7
PRKAA1
PRKAA2
PRKAG1
PRKAG2
SLC31A1
Entrez ID
5562
5564
HPRD ID
04115
04116
Ensembl ID
ENSG00000132356
ENSG00000111725
Uniprot IDs
Q13131
Q9Y478
PDB IDs
4RED
4RER
4REW
5EZV
6C9F
6C9G
6C9H
6C9J
7JHG
7JHH
7JIJ
7M74
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6C9F
6C9G
6C9H
6C9J
7MYJ
8BIK
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Phosphorylation
Regulation Of Macromolecule Metabolic Process
Nucleotide-activated Protein Kinase Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Autophagy
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Nucleoplasm
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Nutrient Levels
AMP-activated Protein Kinase Activity
Protein Phosphorylation
Cytoplasm
Regulation Of Glycolytic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Autophagy
Negative Regulation Of Catabolic Process
Response To Starvation
Protein Binding
Protein Modification Process
Regulation Of Carbohydrate Catabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of ATP Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Protein Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Cell Cycle
Cation Binding
Response To Nutrient Levels
Protein Serine/threonine Phosphatase Activity
Negative Regulation Of TOR Signaling
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
AMP-activated Protein Kinase Activity
Nucleotide-activated Protein Kinase Complex
Regulation Of Glycolytic Process
Regulation Of Carbohydrate Catabolic Process
Regulation Of ATP Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Fatty Acid Biosynthetic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Glucose Starvation
Positive Regulation Of Small Molecule Metabolic Process
Cellular Response To Prostaglandin E Stimulus
Positive Regulation Of Glycolytic Process
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Cellular Response To Prostaglandin Stimulus
Carboxylic Acid Biosynthetic Process
Response To Prostaglandin E
Phosphate-containing Compound Metabolic Process
Regulation Of Carbon Utilization
Fatty Acid Metabolic Process
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of ATP Metabolic Process
Regulation Of Small Molecule Metabolic Process
Protein Localization To Lipid Droplet
Sterol Biosynthetic Process
Negative Regulation Of Tubulin Deacetylation
CAMP-dependent Protein Kinase Activity
Negative Regulation Of Hepatocyte Apoptotic Process
Cellular Response To Starvation
Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
CAMP-dependent Protein Kinase Regulator Activity
Small Molecule Biosynthetic Process
Protein Kinase Binding
Monocarboxylic Acid Metabolic Process
Response To Starvation
Response To Nutrient Levels
Phosphatidylethanolamine Biosynthetic Process
ATP Binding
Organophosphate Biosynthetic Process
Lipid Biosynthetic Process
Regulation Of Protein Deacetylation
Regulation Of Stress Granule Assembly
Cellular Response To Nutrient Levels
Steroid Biosynthetic Process
AMP Binding
Positive Regulation Of TOR Signaling
Response To Hormone
Intracellular Copper Ion Homeostasis
Protein Kinase Regulator Activity
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Tagcloud (Intersection)
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