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PRKAA1 and PRKAG1
Number of citations of the paper that reports this interaction (PubMedID
8663446
)
0
Data Source:
HPRD
(in vitro)
PRKAA1
PRKAG1
Description
protein kinase AMP-activated catalytic subunit alpha 1
protein kinase AMP-activated non-catalytic subunit gamma 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cilium
Apical Plasma Membrane
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Ciliary Basal Body
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Molecular Function
Nucleotide Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein-containing Complex Binding
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Histone H2BS36 Kinase Activity
Nucleotide Binding
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
CAMP-dependent Protein Kinase Regulator Activity
AMP Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
ADP Binding
Protein-containing Complex Binding
Biological Process
Autophagosome Assembly
Response To Hypoxia
Cytoplasmic Translation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glucose Metabolic Process
Chromatin Organization
Chromatin Remodeling
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Phosphatidylethanolamine Biosynthetic Process
Phosphatidylcholine Biosynthetic Process
Steroid Biosynthetic Process
Cholesterol Biosynthetic Process
Autophagy
Lysosome Organization
Signal Transduction
Steroid Metabolic Process
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Xenobiotic Stimulus
Response To UV
Cold Acclimation
Response To Gamma Radiation
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Activity
Wnt Signaling Pathway
Sterol Biosynthetic Process
Fatty Acid Oxidation
Response To Caffeine
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
TORC1 Signaling
Cellular Response To Glucose Starvation
Response To Hydrogen Peroxide
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Estrogen
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Glucosylceramide Biosynthetic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Rhythmic Process
Positive Regulation Of Skeletal Muscle Tissue Development
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Negative Regulation Of Lipid Catabolic Process
Fatty Acid Homeostasis
Regulation Of Vesicle-mediated Transport
Protein Localization To Lysosome
Motor Behavior
CAMKK-AMPK Signaling Cascade
Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Neuron Cellular Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Ethanol
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Protein K6-linked Ubiquitination
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Energy Homeostasis
Hepatocyte Apoptotic Process
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Mitochondrial Transcription
Positive Regulation Of Protein Localization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Protein Localization To Lipid Droplet
Regulation Of Glycolytic Process
Protein Phosphorylation
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Signal Transduction
Spermatogenesis
Cellular Response To Nutrient Levels
Cellular Response To Glucose Starvation
Regulation Of Carbon Utilization
Positive Regulation Of Gluconeogenesis
Import Into Nucleus
Regulation Of Cell Cycle
Pathways
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Adenosine phosphate
Adenosine phosphate
ATP
Phenformin
Acetylsalicylic acid
Fostamatinib
Fostamatinib
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Cardia gastric cancer (
26129866
)
Gastric cancer (
22037551
26098866
26129866
31383772
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Non-cardia gastric cancer (
26129866
26701879
)
Adult body size (
32376654
)
Bipolar disorder (
31043756
)
Body mass index (
29273807
)
HDL cholesterol (
30275531
)
Pulse pressure (
27618447
)
Red cell distribution width (
32888494
)
Systolic blood pressure (
27618447
30578418
)
Interacting Genes
72 interacting genes:
ABI2
ACACA
AGAP2
ATM
BHLHE40
CAB39
CAMKK1
CDX4
CFTR
CHEK1
CRTC2
CTBP1
DVL2
EEF2K
EPM2A
FANCA
FNIP1
GATA1
GOLGA2
GRIK2
HDAC5
HMBOX1
HOMEZ
IKZF3
INO80E
KIF16B
KRT40
L3MBTL3
MAGEA3
MAGEA6
MDM4
MORC4
MTOR
MTUS2
PASK
PFKFB2
PHC2
PNMA5
PPM1A
PPM1E
PPM1F
PPP2CA
PRKAB1
PRKAB2
PRKAG1
PRKAG3
PSMD11
RACK1
RAD54B
RAF1
RBPMS
RFX6
RIMBP3
ROPN1
RPTOR
SLC31A1
SRPK2
SSX2IP
THAP1
TLE5
TOMM34
TRIM27
TRIM28
TRIP6
TSC2
TSC22D4
TXNIP
UBXN11
ULK1
VPS37B
VPS52
ZBED1
31 interacting genes:
ACACA
AP1S3
C1orf94
CBS
CRBN
EIF3G
KCNN4
KEAP1
KLHL20
KRTAP1-1
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP4-12
KRTAP4-2
KRTAP9-2
KRTAP9-8
MEOX1
MEOX2
PAICS
PAX6
PLEKHF2
PRKAA1
PRKAA2
PRKAB1
PRKAB2
PRKAG2
PRKDC
TEKT1
TNFAIP1
Entrez ID
5562
5571
HPRD ID
04115
04118
Ensembl ID
ENSG00000132356
ENSG00000181929
Uniprot IDs
Q13131
F8VYY9
P54619
PDB IDs
4RED
4RER
4REW
5EZV
6C9F
6C9G
6C9H
6C9J
7JHG
7JHH
7JIJ
7M74
2UV4
2UV5
2UV6
2UV7
4CFE
4CFF
4RER
4REW
4ZHX
5EZV
5ISO
6B1U
6B2E
6C9F
6C9G
6C9H
6C9J
7JHG
7JHH
7JIJ
7M74
7MYJ
8BIK
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Phosphorylation
Regulation Of Macromolecule Metabolic Process
Nucleotide-activated Protein Kinase Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Autophagy
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Nucleoplasm
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Nutrient Levels
AMP-activated Protein Kinase Activity
Protein Phosphorylation
Cytoplasm
Regulation Of Glycolytic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Autophagy
Negative Regulation Of Catabolic Process
Response To Starvation
Protein Binding
Protein Modification Process
Regulation Of Carbohydrate Catabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of ATP Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Protein Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Cell Cycle
Cation Binding
Response To Nutrient Levels
Protein Serine/threonine Phosphatase Activity
Negative Regulation Of TOR Signaling
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Keratin Filament
Nucleotide-activated Protein Kinase Complex
Intermediate Filament
AMP-activated Protein Kinase Activity
Carboxylic Acid Biosynthetic Process
Cytosol
Fatty Acid Biosynthetic Process
Small Molecule Biosynthetic Process
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Prostaglandin Stimulus
Fatty Acid Metabolic Process
Response To Prostaglandin E
Protein Localization To Lipid Droplet
Monocarboxylic Acid Metabolic Process
Somite Specification
Carboxylic Acid Metabolic Process
Negative Regulation Of Tubulin Deacetylation
Negative Regulation Of Hepatocyte Apoptotic Process
Organic Acid Metabolic Process
Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Sterol Biosynthetic Process
Cellular Response To Glucose Starvation
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Nutrient Levels
Regulation Of Glycolytic Process
Phosphatidylethanolamine Biosynthetic Process
Cul3-RING Ubiquitin Ligase Complex
Regulation Of Protein Deacetylation
Regulation Of Stress Granule Assembly
Protein Homotetramerization
HMG Box Domain Binding
Regulation Of Carbohydrate Catabolic Process
Response To Nutrient Levels
L-serine Metabolic Process
Hair Cycle
Segment Specification
Somite Development
Regulation Of ATP Metabolic Process
Lipid Biosynthetic Process
Fatty Acid Homeostasis
Hepatocyte Apoptotic Process
Protein Homooligomerization
Regulation Of Purine Nucleotide Metabolic Process
Steroid Biosynthetic Process
Protein Tetramerization
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Phosphatidylcholine Biosynthetic Process
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