NAGK and DSCR9

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NAGK	DSCR9
Description		N-acetylglucosamine kinase	Down syndrome critical region 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cellular_component
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity	Molecular_function
	Biological Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination	Biological_process
Pathways		Synthesis of UDP-N-acetyl-glucosamine
Drugs		N-Acetylglucosamine
Diseases
GWAS		Blood protein levels ( 30072576) Erythema nodosum in inflammatory bowel disease ( 24487271)	Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2
Entrez ID		55577	257203
HPRD ID		08441	10925
Ensembl ID		ENSG00000124357	ENSG00000230366
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70
PDB IDs		2CH5 2CH6
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway
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