DSCR9 and LRP4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	LRP4
Description		Down syndrome critical region 9	LDL receptor related protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Plasma Membrane Raft Synapse Synaptic Membrane
	Molecular Function	Molecular_function	Calcium Ion Binding Protein Binding Coreceptor Activity Receptor Tyrosine Kinase Binding Apolipoprotein Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Biological_process	Kidney Development Hair Follicle Development Endocytosis Enzyme-linked Receptor Protein Signaling Pathway Intracellular Protein Localization Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Embryonic Limb Morphogenesis Positive Regulation Of Rac Protein Signal Transduction Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Receptor Clustering Generation Of Neurons System Development Dendrite Morphogenesis Negative Regulation Of Axonogenesis Synapse Organization Synaptic Assembly At Neuromuscular Junction Limb Development Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Postsynapse Assembly Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways			ECM proteoglycans
Drugs
Diseases			Cenani-Lenz syndactyly syndrome
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 19079262) D-dimer levels ( 21502573) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Intraocular pressure ( 29617998) Mood instability ( 31168069) Pre-treatment viral load in HIV-1 infection ( 31219150) Reaction time ( 29844566) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Venous thromboembolism ( 31420334)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	5 interacting genes: DSCR9 DYRK1A LCOR OGT WHRN
Entrez ID		257203	4038
HPRD ID		10925	18517
Ensembl ID		ENSG00000230366	ENSG00000134569
Uniprot IDs			O75096
PDB IDs			8S9P
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Actin Filament Histone H3T45 Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Circadian Rhythm Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Stereocilia Ankle Link Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Carbon Catabolite Regulation Of Transcription Rhythmic Process Regulation Of Heterochromatin Formation Regulation Of Transcription By Glucose RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Gene Expression Neurofilament NSL Complex Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Stereocilium Bundle
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