DSCR9 and NIPBL

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	NIPBL
Description		Down syndrome critical region 9	NIPBL cohesin loading factor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Chromatin Nucleus Nucleoplasm Chromosome Cytosol Integrator Complex SMC Loading Complex Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	Molecular_function	Chromatin Binding Transcription Corepressor Activity Protein Binding Mediator Complex Binding Histone Deacetylase Binding Cohesin Loader Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Biological_process	Mitotic Sister Chromatid Segregation Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Mitotic Sister Chromatid Cohesion Brain Development Heart Development Sensory Perception Of Sound Intracellular Protein Localization Regulation Of Gene Expression Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gallbladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways			Cohesin Loading onto Chromatin
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Height ( 25282103 28552196 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	11 interacting genes: CBX5 CDK6 DBN1 DSCR9 HINFP MAP1LC3C PCNA PCNT PRSS23 SP100 SUMO2
Entrez ID		257203	25836
HPRD ID		10925	10560
Ensembl ID		ENSG00000230366	ENSG00000164190
Uniprot IDs			A0A590UJS4 Q6KC79
PDB IDs			6WG3 6WGE 7W1M
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	DNA Damage Response Generation Of Neurons PML Body Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Postsynaptic Cytosol Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Maintenance Of Protein Location In Cell PCNA Complex Replisome Negative Regulation Of DNA-templated Transcription G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Cell Communication By Chemical Coupling Maintenance Of Protein Location Maintenance Of Location In Cell Maintenance Of Location PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neurogenesis Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of Fas Signaling Pathway
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