NAGK and NUDC

Number of citations of the paper that reports this interaction (PubMedID 33374456)
81

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NAGK	NUDC
Description		N-acetylglucosamine kinase	nuclear distribution C, dynein complex regulator
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Midbody Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity	Protein Binding Cadherin Binding Unfolded Protein Binding
	Biological Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination	Protein Folding Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Nuclear Migration Response To Peptide Hormone Cell Division Establishment Of Organelle Localization
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation RND2 GTPase cycle
Drugs		N-Acetylglucosamine	Phenethyl Isothiocyanate
Diseases
GWAS		Blood protein levels ( 30072576) Erythema nodosum in inflammatory bowel disease ( 24487271)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lipoprotein (a) levels ( 33730874) Plateletcrit ( 27863252)
Interacting Genes		36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	8 interacting genes: ACD CEBPA NAGK OGT PAFAH1B1 PLK1 POT1 TINF2
Entrez ID		55577	10726
HPRD ID		08441	10122
Ensembl ID		ENSG00000124357	ENSG00000090273
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	Q9Y266
PDB IDs		2CH5 2CH6	3QOR 7NDX
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Organelle Organization Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Microtubule Organizing Center Organization Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Chromosome Organization Regulation Of Telomere Maintenance Nuclear Membrane Disassembly Membrane Disassembly Telomere Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Organelle Organization Protein Localization To Organelle Centrosome Cycle Nuclear Membrane Organization Microtubule Cytoskeleton
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