NAGK and GNPNAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NAGK	GNPNAT1
Description		N-acetylglucosamine kinase	glucosamine-phosphate N-acetyltransferase 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Golgi Membrane Cytoplasm Endosome Late Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endosome Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity	Glucosamine 6-phosphate N-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Identical Protein Binding
	Biological Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination	UDP-N-acetylglucosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Synthesis of UDP-N-acetyl-glucosamine
Drugs		N-Acetylglucosamine
Diseases
GWAS		Blood protein levels ( 30072576) Erythema nodosum in inflammatory bowel disease ( 24487271)	Blood protein levels ( 30072576) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	3 interacting genes: C1QA NAGK PSMB8
Entrez ID		55577	64841
HPRD ID		08441	17046
Ensembl ID		ENSG00000124357	ENSG00000100522
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	Q96EK6
PDB IDs		2CH5 2CH6	2HUZ 2O28 3CXP 3CXQ 3CXS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Complement Component C1q Complex IgM Binding Complement Component C1 Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Spermatoproteasome Complex N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process N-acetylglucosamine Catabolic Process Muramyl Dipeptide Kinase Activity Extrinsic Component Of Postsynaptic Membrane Activation Of Immune Response Immune System Process Synapse Pruning Threonine-type Endopeptidase Activity UDP-N-acetylglucosamine Biosynthetic Process Protein Linear Polyubiquitination Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process Neuron Remodeling IgG Binding Proteasome Core Complex, Beta-subunit Complex UDP-N-acetylglucosamine Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway N-acetylglucosamine Metabolic Process Symbiont Cell Surface Astrocyte Activation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome Core Complex Carbohydrate Phosphorylation Response To Muramyl Dipeptide Innate Immune Response Positive Regulation Of Immune Response P38MAPK Cascade Nucleotide-sugar Biosynthetic Process Neuron Maturation Microglial Cell Activation Defense Response To Symbiont Leukocyte Activation Involved In Inflammatory Response Defense Response To Other Organism Complement Activation, Classical Pathway Amino Sugar Metabolic Process Nucleotide-sugar Metabolic Process Regulation Of Immune Response Complement Activation Positive Regulation Of Immune System Process
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