NAGK and GNPNAT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NAGK	GNPNAT1
Gene Name		N-acetylglucosamine kinase	glucosamine-phosphate N-acetyltransferase 1
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Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Golgi Membrane Late Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Endosome Membrane
	Molecular Function	Protein Binding ATP Binding N-acylmannosamine Kinase Activity N-acetylglucosamine Kinase Activity	Glucosamine 6-phosphate N-acetyltransferase Activity Monosaccharide Binding
	Biological Process	N-acetylglucosamine Metabolic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation	Liver Development Glucosamine Metabolic Process N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Synthesis of UDP-N-acetyl-glucosamine Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		27 interactors: ACTR10 CCDC158 CDKN2C DACH1 DCP2 DYNC1I1 FGFR1OP GNPNAT1 LACTB2 LENG1 LNX1 LSM8 MEOX1 MTHFD2 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 STK16 SYNE4 TCF12 TNNT1 WDR82	2 interactors: C1QA NAGK
Entrez ID		55577	64841
HPRD ID		08441	17046
Ensembl ID		ENSG00000124357	ENSG00000100522
Uniprot IDs		C9JEV6 Q9UJ70	Q96EK6
PDB IDs		2CH5 2CH6	2HUZ 2O28 3CXP 3CXQ 3CXS
Enriched GO Terms of Interacting Partners?			N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process N-acetylneuraminate Metabolic Process N-acetylglucosamine Metabolic Process Amino Sugar Metabolic Process Carbohydrate Phosphorylation
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