DSCR9 and BICD2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	BICD2
Description		Down syndrome critical region 9	BICD cargo adaptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Molecular_function	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Biological_process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center
Pathways			COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Appendicular lean mass ( 33097823) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	51 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX DSCR9 FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 NXF1 PCM1 PMF1 POLDIP3 PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 RAB6A RAB6B RBM22 RBM41 SNW1 TBRG4 TCEA2 TCEANC TFIP11 TSGA10IP USP2 UTP14A UTP14C YES1 YTHDF1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23
Entrez ID		257203	23299
HPRD ID		10925	09826
Ensembl ID		ENSG00000230366	ENSG00000185963
Uniprot IDs			Q8TD16 Q96FU2
PDB IDs			6OFP 6PSE
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Centrosome Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process MRNA Metabolic Process U2-type Precatalytic Spliceosome Ciliary Basal Body Nuclear Speck Microtubule Cytoskeleton Organization Microtubule Anchoring Protein Localization To Golgi Membrane Catalytic Step 2 Spliceosome Spindle Microtubule Nucleoplasm Protein Binding Microtubule Anchoring At Centrosome Nucleus Microtubule-based Process Nucleic Acid Metabolic Process Microtubule Anchoring At Microtubule Organizing Center Microtubule Binding Cellular Response To Retinoic Acid Myosin V Binding Establishment Of Organelle Localization Zinc Ion Binding Spindle Pole Spliceosomal Tri-snRNP Complex Assembly Centriole Nucleic Acid Binding Positive Regulation Of Protein Export From Nucleus U5 SnRNP
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