DSCR9 and PLEKHB1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	PLEKHB1
Description		Down syndrome critical region 9	pleckstrin homology domain containing B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytoplasm Membrane
	Molecular Function	Molecular_function	Protein Binding
	Biological Process	Biological_process	Phototransduction Regulation Of Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Dimensional psychopathology (Cognitive) ( 29496196) Glucose homeostasis traits ( 25524916) Hand grip strength ( 27325353) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	18 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B BTG3 C10orf55 CCR8 DSCR9 GLIS2 GNGT1 LCOR RAP1GDS1 RBM11 RUNX1 SMAD1 TGFBR1 VENTX ZDHHC17
Entrez ID		257203	58473
HPRD ID		10925	09630
Ensembl ID		ENSG00000230366	ENSG00000021300
Uniprot IDs			Q9UF11
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I SMAD Binding Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Activin Binding Regulation Of Cartilage Development BMP Signaling Pathway Striated Muscle Cell Apoptotic Process Cellular Response To Growth Factor Stimulus Pharyngeal System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Apoptotic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process Response To Growth Factor Osteoblast Differentiation Positive Regulation Of Extracellular Matrix Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Pattern Specification Process Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Cell Fate Commitment Positive Regulation Of Vasculature Development Regulation Of Cardiac Muscle Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Growth Factor Binding Endocardial Cushion Cell Fate Commitment CAAX-box Protein Maturation Perforant Pathway To Dendrate Granule Cell Synapse Cellular Developmental Process
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