ORC3 and ORC4

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, pull down)
HPRD (in vivo, in vitro)

		ORC3	ORC4
Description		origin recognition complex subunit 3	origin recognition complex subunit 4
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Chromosome Nuclear Body DNA Replication Preinitiation Complex	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol
	Molecular Function	DNA Binding DNA Replication Origin Binding Protein Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication Glial Cell Proliferation Neural Precursor Cell Proliferation	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Obesity-related traits ( 23251661)	Estimated glomerular filtration rate ( 30604766 31015462 31152163) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		22 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 CEBPA DBF4 FBXO7 H3-4 H4C16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4
Entrez ID		23595	5000
HPRD ID		05398	09118
Ensembl ID		ENSG00000135336	ENSG00000115947
Uniprot IDs		Q9UBD5	A8K7H4 O43929 Q96B14
PDB IDs		5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Origin Binding DNA Replication Chromosome, Telomeric Region DNA Metabolic Process Origin Recognition Complex Nuclear Origin Of Replication Recognition Complex Nucleoplasm Nucleus CMG Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Regulation Of Cell Cycle Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding MCM Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Chromosome Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Binding Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Mitotic DNA Replication Checkpoint Signaling DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition ATP Binding DNA Recombination Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Elongation Chromatin Binding Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response	DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?