ORC3 and CCNE2

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		ORC3	CCNE2
Description		origin recognition complex subunit 3	cyclin E2
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Chromosome Nuclear Body DNA Replication Preinitiation Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	DNA Binding DNA Replication Origin Binding Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication Glial Cell Proliferation Neural Precursor Cell Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS		Obesity-related traits ( 23251661)	Keratoconus ( 33649486)
Interacting Genes		22 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 CEBPA DBF4 FBXO7 H3-4 H4C16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		23595	9134
HPRD ID		05398	04801
Ensembl ID		ENSG00000135336	ENSG00000175305
Uniprot IDs		Q9UBD5	O96020
PDB IDs		5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	8HN9
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Origin Binding DNA Replication Chromosome, Telomeric Region DNA Metabolic Process Origin Recognition Complex Nuclear Origin Of Replication Recognition Complex Nucleoplasm Nucleus CMG Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Regulation Of Cell Cycle Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding MCM Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Chromosome Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Binding Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Mitotic DNA Replication Checkpoint Signaling DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition ATP Binding DNA Recombination Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Elongation Chromatin Binding Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response	Cyclin Binding Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of DNA Replication Ubiquitin Protein Ligase Binding Molecular Function Inhibitor Activity Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Inhibitor Activity Positive Regulation Of Protein Catabolic Process Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Protein Tag Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Exit From Mitosis Negative Regulation Of Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Epithelial Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?