ORC3 and DBF4

Number of citations of the paper that reports this interaction (PMID 12441400)
37

Data Source:
HPRD (two hybrid, in vivo)

		ORC3	DBF4
Gene Name		origin recognition complex, subunit 3	DBF4 zinc finger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleoplasm Nuclear Origin Of Replication Recognition Complex	Nucleoplasm
	Molecular Function	DNA Replication Origin Binding Protein Binding	Nucleic Acid Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Neural Precursor Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Positive Regulation Of Catalytic Activity
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: APP CCNE2 CDC45 CDC6 CDK4 DBF4 HIST3H3 HIST4H4 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 TERF2	17 interactors: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		23595	10926
HPRD ID		05398	10371
Ensembl ID		ENSG00000135336	ENSG00000006634
Uniprot IDs		Q9UBD5	B7Z8C6 Q9UBU7
PDB IDs			4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Replication Initiation Mitotic Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication Cellular Macromolecule Biosynthetic Process DNA Strand Elongation Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cellular Metabolic Process DNA Duplex Unwinding Biosynthetic Process DNA Geometric Change Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Conformation Change Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Telomere Maintenance DNA Replication Checkpoint DNA Unwinding Involved In DNA Replication Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Organelle Organization Regulation Of Mitotic Cell Cycle Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Replication Cell Cycle Checkpoint	DNA Replication DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Conformation Change Cellular Response To DNA Damage Stimulus Chromosome Organization Cellular Metabolic Process Regulation Of DNA Replication DNA Repair Cellular Response To Stress Organelle Organization Regulation Of Nuclear Cell Cycle DNA Replication Signal Transduction In Response To DNA Damage Positive Regulation Of DNA-dependent DNA Replication Metabolic Process Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus DNA Damage Checkpoint Response To Epidermal Growth Factor Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of DNA Replication Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition
Tagcloud ?			bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Difference) ?			bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Intersection) ?