ORC3 and ORC1

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		ORC3	ORC1
Description		origin recognition complex subunit 3	origin recognition complex subunit 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Chromosome Nuclear Body DNA Replication Preinitiation Complex	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	DNA Binding DNA Replication Origin Binding Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication Glial Cell Proliferation Neural Precursor Cell Proliferation	DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		22 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 CEBPA DBF4 FBXO7 H3-4 H4C16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	25 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 H4C1 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 XPO1
Entrez ID		23595	4998
HPRD ID		05398	03544
Ensembl ID		ENSG00000135336	ENSG00000085840
Uniprot IDs		Q9UBD5	B7Z8H0 Q13415 Q96F82
PDB IDs		5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Origin Binding DNA Replication Chromosome, Telomeric Region DNA Metabolic Process Origin Recognition Complex Nuclear Origin Of Replication Recognition Complex Nucleoplasm Nucleus CMG Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Regulation Of Cell Cycle Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding MCM Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Chromosome Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Binding Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Mitotic DNA Replication Checkpoint Signaling DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition ATP Binding DNA Recombination Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Elongation Chromatin Binding Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response	DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process CMG Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Nuclear Origin Of Replication Recognition Complex Recombinational Repair Nucleoplasm MCM Complex DNA Repair Double-strand Break Repair DNA Recombination Origin Recognition Complex Single-stranded DNA Binding DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA-templated DNA Replication Nucleus Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Cellular Response To Stress Helicase Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling DNA Replication Preinitiation Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Replication Checkpoint Signaling
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