APTX and FLAD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APTX	FLAD1
Description		aprataxin	flavin adenine dinucleotide synthetase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Catalytic Activity Protein Binding Zinc Ion Binding Phosphoglycolate Phosphatase Activity Hydrolase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Phosphoprotein Binding DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding	Nucleotide Binding Catalytic Activity FMN Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding FAD Diphosphatase Activity
	Biological Process	Single Strand Break Repair DNA Repair DNA Damage Response Regulation Of Protein Stability	FAD Biosynthetic Process Riboflavin Metabolic Process Flavin Adenine Dinucleotide Biosynthetic Process
Pathways			Vitamin B2 (riboflavin) metabolism
Drugs
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Coenzyme Q10 deficiency
GWAS		Height ( 28552196) Menopause (age at onset) ( 26414677)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	21 interacting genes: ANXA7 APTX CDKN1A CLVS2 COPS3 CRABP2 DNM2 FXR1 GEMIN4 GRB7 L3MBTL3 NIF3L1 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23
Entrez ID		54840	80308
HPRD ID		05892	17887
Ensembl ID		ENSG00000137074	ENSG00000160688
Uniprot IDs		A0A5K1VW64 Q7Z2E3	Q8NFF5
PDB IDs		3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT	8ROM 8RON
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Mitochondrial DNA Repair Nucleolus Enzyme Binding Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Cellular Component Organization Double-strand Break Repair Negative Regulation Of Chromosome Organization Chromatin Binding Site Of Double-strand Break Mitochondrial DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of Catalytic Activity Protein Localization To Organelle Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Protein Localization To Site Of Double-strand Break Response To X-ray Negative Regulation Of DNA Replication NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Metalloendopeptidase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Cell Growth Base-excision Repair Oxidized DNA Binding FHA Domain Binding FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity DNA Repair	Nucleus Identical Protein Binding SMN Complex Gemini Of Cajal Bodies Cytoplasm Cellular Component Assembly SMN-Sm Protein Complex Protein-containing Complex Assembly MRNA 3'-UTR AU-rich Region Binding Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Nuclear Body Cyclin Binding Cell Cycle Phase Transition Protein Sequestering Activity Protein Heterodimerization Activity Lipid Binding Protein-containing Complex Organization Interleukin-5 Receptor Complex Spliceosomal SnRNP Assembly Ribonucleoprotein Complex Binding Positive Regulation Of Pro-B Cell Differentiation DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Nucleoside Metabolic Process
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