APTX and HIVEP1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	HIVEP1
Gene Name		aprataxin	human immunodeficiency virus type I enhancer binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	35 interactors: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BHLHE40 BNIP3 BRCA1 CACNA1A DNAJA1 EMG1 GAA GSDMB HPD HRSP12 HSPA1A IMMT MAGED1 MAPK14 MAPK8 MTMR3 NHLH1 NINJ1 NUCB1 PRKAR1A RAB1A SDCBP SERTAD1 SMAD3 SNX4 SOCS3 SOX10 STAT3 TMEM176A
Entrez ID		54840	3096
HPRD ID		05892	01925
Ensembl ID		ENSG00000137074	ENSG00000095951
Uniprot IDs		Q7Z2E3	P15822
PDB IDs		3KT9	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Signaling Regulation Of Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Stress Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Growth Regulation Of Phosphorylation Glucose Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cell Death Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Hexose Metabolic Process Positive Regulation Of Organelle Organization
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	16q22 aboriginal cholestasis cirh1a cirhin cirip cirrhosis collaboration evolves focuses helped hopital indian justine mapped naic nations northwestern nucleolus portal quebec r565w researchers splice ste tex292 twelve varices wd40
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	16q22 aboriginal cholestasis cirh1a cirhin cirip cirrhosis collaboration evolves focuses helped hopital indian justine mapped naic nations northwestern nucleolus portal quebec r565w researchers splice ste tex292 twelve varices wd40
Tagcloud (Intersection) ?