APTX and SYT17

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	SYT17
Gene Name		aprataxin	synaptotagmin XVII
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Trans-Golgi Network Synaptic Vesicle Membrane
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	Transporter Activity
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Exocytosis
Pathways
Drugs
Diseases
GWAS			Alcohol dependence ( 21876473)
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	18 interactors: APP APTX CCDC85B CEP63 CEP70 CHMP4A FAM9B GMCL1 IKZF1 MEOX1 MEOX2 MID2 NIF3L1 NINL RUNDC3A SSX2IP TRAF2 TSC22D4
Entrez ID		54840	51760
HPRD ID		05892	17425
Ensembl ID		ENSG00000137074
Uniprot IDs		Q7Z2E3	H3BN78 H3BRH9 Q9BSW7
PDB IDs		3KT9	2ENP
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	Somite Specification Segment Specification G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Neutrophil Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Neuron Death Mitotic Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Polynucleotide 3' Dephosphorylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Mitotic Cell Cycle Somitogenesis Positive Regulation Of Transcription, DNA-templated Embryonic Pattern Specification Cell Cycle Centrosome Organization Negative Regulation Of Autophagic Vacuole Assembly Dihydrobiopterin Metabolic Process Collateral Sprouting In Absence Of Injury Somite Development Regulation Of Multicellular Organism Growth Negative Regulation Of Cellular Metabolic Process Microtubule Organizing Center Organization Sclerotome Development Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Segmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Microtubule-based Transport Intraciliary Transport Involved In Cilium Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cytoskeleton-dependent Intracellular Transport Positive Regulation Of NK T Cell Differentiation Viral Budding Via Host ESCRT Complex Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Binding
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Intersection) ?