APTX and TSPYL2

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	TSPYL2
Gene Name		aprataxin	TSPY-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Plasma Membrane
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	RDNA Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Chromatin Modification Negative Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	9 interactors: APTX CASK CCNB1 CDK1 CDK2 CDK4 COIL EEF1A1 GFI1B
Entrez ID		54840	64061
HPRD ID		05892	06713
Ensembl ID		ENSG00000137074	ENSG00000184205
Uniprot IDs		Q7Z2E3	Q9H2G4
PDB IDs		3KT9
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Response To Inorganic Substance Histone Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Ventricular Cardiac Muscle Cell Development Response To Toxic Substance Protein Phosphorylation Chromatin Modification Response To Reactive Oxygen Species Regulation Of Protein Ubiquitination Ventricular Cardiac Muscle Cell Differentiation Mitotic Cell Cycle Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Heart Growth Phosphate-containing Compound Metabolic Process Nuclear Envelope Disassembly Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Chromosome Condensation Positive Regulation Of Organ Growth Mitotic Nuclear Division Cellular Nitrogen Compound Metabolic Process Response To Metal Ion Phosphorylation Regulation Of Cell Cycle Centrosome Cycle Regulation Of Heart Growth
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously
Tagcloud (Intersection) ?