APTX and ZNF639

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	ZNF639
Gene Name		aprataxin	zinc finger protein 639
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Self-association Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Transcription, DNA-templated Positive Regulation Of Cell Growth Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Entry Into Host Cell
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	3 interactors: APTX CREBBP PNKP
Entrez ID		54840	51193
HPRD ID		05892	15882
Ensembl ID		ENSG00000137074	ENSG00000121864
Uniprot IDs		Q7Z2E3	Q9UID6
PDB IDs		3KT9
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	Polynucleotide 3' Dephosphorylation DNA Catabolic Process Cellular Response To Stress N-terminal Peptidyl-lysine Acetylation Nucleic Acid Phosphodiester Bond Hydrolysis Germ-line Stem Cell Maintenance Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Aromatic Compound Catabolic Process Dephosphorylation N-terminal Protein Amino Acid Acetylation DNA Ligation DNA Repair Nucleotide-excision Repair, DNA Damage Removal Single Strand Break Repair Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress N-terminal Protein Amino Acid Modification DNA Catabolic Process, Exonucleolytic Cellular Response To DNA Damage Stimulus Regulation Of Cellular Response To Heat Cellular Macromolecule Catabolic Process DNA Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Nucleotide Phosphorylation Nucleobase-containing Compound Metabolic Process Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Embryonic Digit Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Nucleotide-excision Repair Regulation Of Smoothened Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nitrogen Compound Metabolic Process
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Intersection) ?