APTX and CNTROB

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	CNTROB
Gene Name		aprataxin	centrobin, centrosomal BRCA2 interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Cytoplasm Centrosome Centriole
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Centriole Replication Centrosome Separation Mitotic Cytokinetic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	4 interactors: APTX COASY LYST TTC23
Entrez ID		54840	116840
HPRD ID		05892	13991
Ensembl ID		ENSG00000137074	ENSG00000170037
Uniprot IDs		Q7Z2E3	Q8N137
PDB IDs		3KT9
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	Mast Cell Secretory Granule Organization Polynucleotide 3' Dephosphorylation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Secretion Of Lysosomal Enzymes Phospholipid Homeostasis Pantothenate Metabolic Process DNA Ligation Phosphate-containing Compound Metabolic Process Coenzyme A Biosynthetic Process Early Endosome To Late Endosome Transport Neutrophil Mediated Immunity Melanosome Organization Single Strand Break Repair Pigment Granule Organization Defense Response To Protozoan Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Activation Coenzyme A Metabolic Process Natural Killer Cell Mediated Immunity Response To Protozoan DNA Catabolic Process, Exonucleolytic Leukocyte Mediated Cytotoxicity T Cell Mediated Immunity Secretory Granule Organization Organophosphate Metabolic Process Anion Homeostasis Lysosome Organization Cellular Pigmentation Water-soluble Vitamin Metabolic Process
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Intersection) ?