APTX and CALCOCO1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APTX	CALCOCO1
Gene Name		aprataxin	calcium binding and coiled-coil domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nuclear Chromatin Nucleus Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding	Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Armadillo Repeat Domain Binding
	Biological Process	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation	Transcription, DNA-templated Signal Transduction Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Panic disorder ( 19165232)
Protein-Protein Interactions		16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	26 interactors: APP APTX CEP19 CREBBP CRYBA2 CTNNBL1 CWF19L2 CYTH3 DUSP13 EP300 FAM161A FOSL1 GABARAPL2 GRIK2 HIST1H3A HIST1H4A IPP ISOC1 KRT15 MAPK1 NDC80 NEDD4 PCBD1 SH3GL3 TBC1D15 TBC1D17
Entrez ID		54840	57658
HPRD ID		05892	13868
Ensembl ID		ENSG00000137074	ENSG00000012822
Uniprot IDs		Q7Z2E3	Q9P1Z2
PDB IDs		3KT9
Enriched GO Terms of Interacting Partners?		Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process	N-terminal Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress DNA Replication-dependent Nucleosome Assembly Cellular Response To Heat N-terminal Protein Amino Acid Acetylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Protein Stability N-terminal Protein Amino Acid Modification Notch Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Binding Establishment Of Localization In Cell Intracellular Transport Response To Abiotic Stimulus Chromatin Silencing Placenta Blood Vessel Development Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction Response To Temperature Stimulus Positive Regulation Of Metabolic Process Response To Stress Posttranscriptional Regulation Of Gene Expression Histone H2B Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Neuromuscular Junction Development Regulation Of Metabolic Process Neuron Apoptotic Process Defense Response Cellular Localization Glutamate Receptor Signaling Pathway DNA Methylation Cellular Component Assembly Regulation Of Signaling Viral Process Neuron Death MAPK Import Into Nucleus Synaptic Growth At Neuromuscular Junction Polynucleotide 3' Dephosphorylation Vitellogenesis Regulation Of Binding Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Programmed Cell Death
Tagcloud ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	americans arg12his carm1 cataloging coding corepressor crebbp ep300 estrogens ethnic foxa1 hawaiians his52arg latinos mpg multiethnic ncoa1 ncoa2 ncoa3 ncor1 ncor2 nme1 nominally pparbp prmt1 smarca2 smarca4 steroid synonymous
Tagcloud (Difference) ?		accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates	americans arg12his carm1 cataloging coding corepressor crebbp ep300 estrogens ethnic foxa1 hawaiians his52arg latinos mpg multiethnic ncoa1 ncoa2 ncoa3 ncor1 ncor2 nme1 nominally pparbp prmt1 smarca2 smarca4 steroid synonymous
Tagcloud (Intersection) ?