APTX and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 15367657)
35

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (two hybrid, in vitro, in vivo)

		APTX	XRCC1
Description		aprataxin	X-ray repair cross complementing 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Catalytic Activity Protein Binding Zinc Ion Binding Phosphoglycolate Phosphatase Activity Hydrolase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Phosphoprotein Binding DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Single Strand Break Repair DNA Repair DNA Damage Response Regulation Of Protein Stability	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways			Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Coenzyme Q10 deficiency
GWAS		Height ( 28552196) Menopause (age at onset) ( 26414677)	Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	21 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 TOPORS UBE2I UHRF2
Entrez ID		54840	7515
HPRD ID		05892	01909
Ensembl ID		ENSG00000137074	ENSG00000073050
Uniprot IDs		A0A5K1VW64 Q7Z2E3	B2RCY5 P18887 Q59HH7
PDB IDs		3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Mitochondrial DNA Repair Nucleolus Enzyme Binding Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Cellular Component Organization Double-strand Break Repair Negative Regulation Of Chromosome Organization Chromatin Binding Site Of Double-strand Break Mitochondrial DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of Catalytic Activity Protein Localization To Organelle Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Protein Localization To Site Of Double-strand Break Response To X-ray Negative Regulation Of DNA Replication NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Metalloendopeptidase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Cell Growth Base-excision Repair Oxidized DNA Binding FHA Domain Binding FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity DNA Repair	Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
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