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PPP1R12C and CACNA1A
Number of citations of the paper that reports this interaction (PMID
21078624
)
14
Data Source:
BioGRID
(two hybrid)
PPP1R12C
CACNA1A
Gene Name
protein phosphatase 1, regulatory subunit 12C
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Nucleus
Cytoplasm
Plasma Membrane
Voltage-gated Calcium Channel Complex
Integral Component Of Membrane
Dendrite
Cell Projection
Neuronal Cell Body
Molecular Function
Protein Binding
Voltage-gated Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Syntaxin Binding
Metal Ion Binding
Biological Process
Sulfur Amino Acid Metabolic Process
Glucose Metabolic Process
Energy Reserve Metabolic Process
Positive Regulation Of Cytosolic Calcium Ion Concentration
Gamma-aminobutyric Acid Signaling Pathway
Synaptic Transmission
Neuromuscular Synaptic Transmission
Synapse Assembly
Adult Walking Behavior
Cell Death
Gamma-aminobutyric Acid Secretion
Regulation Of Acetylcholine Secretion, Neurotransmission
Cell Growth
Calcium Ion-dependent Exocytosis
Regulation Of Calcium Ion-dependent Exocytosis
Transmission Of Nerve Impulse
Spinal Cord Motor Neuron Differentiation
Cerebellum Maturation
Cerebellar Molecular Layer Development
Cerebellar Purkinje Cell Differentiation
Vestibular Nucleus Development
Cellular Chloride Ion Homeostasis
Negative Regulation Of Hormone Biosynthetic Process
Regulation Of Ion Transmembrane Transport
Synaptic Transmission, Glutamatergic
Neurotransmitter Metabolic Process
Hormone Metabolic Process
Receptor Clustering
Negative Regulation Of Neuron Apoptotic Process
Small Molecule Metabolic Process
Behavioral Response To Pain
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Dendrite Morphogenesis
Regulation Of Axonogenesis
Regulation Of Insulin Secretion
Musculoskeletal Movement, Spinal Reflex Action
Neuromuscular Process Controlling Balance
Membrane Depolarization
Rhythmic Synaptic Transmission
Calcium Ion Import
Calcium Ion Transmembrane Transport
Membrane Depolarization During Action Potential
Pathways
Integration of energy metabolism
Regulation of insulin secretion
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Transmission across Chemical Synapses
Drugs
Pregabalin
Verapamil
Loperamide
Bepridil
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
ATXN7
C1orf109
CACNA1A
CDC42BPA
IL16
MPRIP
MYL2
PAFAH1B2
PPP1CB
RBM17
SMAD3
92 interactors:
ABCA2
ABI1
ACTN1
AGRN
ALDOA
AMIGO2
AP2M1
ARHGAP22
ASNA1
BTG3
BZRAP1
C1QTNF1
CABP1
CACNB1
CACNB4
CALM2
CALM3
CKAP5
CRIM1
CRMP1
CSNK2B
CYSRT1
DNAJB5
EFEMP1
EFEMP2
EHMT2
EIF3A
FBLN1
GNB1
GOLGA6L5P
GRN
HECW1
HHATL
HIVEP1
HSPG2
IP6K1
JAG2
KALRN
KHDRBS3
KIAA1191
LAMB1
LLGL1
LPHN1
LRP1
LTBP1
LTBP3
LTBP4
MANBAL
MATK
MATN2
MEGF6
MEGF8
MIA3
MOAP1
NDUFB8
NELFCD
NELL1
NELL2
NOTCH1
NOXA1
OLIG1
PCSK5
PCSK6
PMM1
PPIG
PPM1A
PPP1R12C
PTGDS
PUF60
RBM12B
RIMBP2
RPL31
RPS17
SCP2
SPRY1
SRRM4
SRSF1
SUMF2
SYT1
TAF15
TELO2
TSC22D1
TSPAN7
TUBB2B
UQCRC2
VARS
VPS52
VWF
WBP1
YLPM1
ZCCHC17
ZNF233
Entrez ID
54776
773
HPRD ID
11452
03004
Ensembl ID
ENSG00000125503
ENSG00000141837
Uniprot IDs
B4DME2
Q9BZL4
B5TYJ1
O00555
Q9NS89
PDB IDs
3BXK
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Positive Chemotaxis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cerebellar Molecular Layer Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Muscle Cell Fate Specification
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Chemotaxis
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Vestibular Nucleus Development
Actomyosin Structure Organization
Positive Regulation Of Behavior
Regulation Of Chemotaxis
Cerebellum Maturation
Musculoskeletal Movement, Spinal Reflex Action
Evasion Or Tolerance Of Host Defenses By Virus
Energy Reserve Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Gamma-aminobutyric Acid Secretion
Negative Regulation Of Cell Growth
Regulation Of Extracellular Matrix Assembly
Regulation Of Acetylcholine Secretion, Neurotransmission
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Behavior
Rhythmic Synaptic Transmission
Primary MiRNA Processing
Response To Transforming Growth Factor Beta
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Regulation Of Glycogen Catabolic Process
Negative Regulation Of Osteoblast Proliferation
SMAD Protein Complex Assembly
Heart Morphogenesis
Response To External Stimulus
Cellular Chloride Ion Homeostasis
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Transforming Growth Factor Beta2 Production
Chloride Ion Homeostasis
Transdifferentiation
Gamma-aminobutyric Acid Transport
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Growth
Lipid Catabolic Process
Positive Regulation Of Catenin Import Into Nucleus
Negative Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Alkaline Phosphatase Activity
Pons Development
Secretion By Cell
Secretion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Voltage-gated Calcium Channel Activity
Detection Of Visible Light
Enzyme Linked Receptor Protein Signaling Pathway
Detection Of Light Stimulus
Multicellular Organismal Development
Phototransduction, Visible Light
Anatomical Structure Development
Cellular Localization
Axon Development
Developmental Process
Establishment Of Localization In Cell
Phototransduction
Regulation Of Cellular Process
System Development
Axonogenesis
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Detection Of Abiotic Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Platelet Degranulation
Cell Morphogenesis Involved In Neuron Differentiation
Anatomical Structure Morphogenesis
Regulation Of Cation Channel Activity
Axon Guidance
Nervous System Development
Detection Of Calcium Ion
Regulation Of Intracellular Cholesterol Transport
Regulation Of Cell Communication By Electrical Coupling
Neuron Projection Morphogenesis
Exocytosis
Neuron Projection Development
Cellular Response To Growth Factor Stimulus
Neuron Differentiation
Inositol Phosphate Metabolic Process
Cell Projection Morphogenesis
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Cell Morphogenesis Involved In Differentiation
Cell Part Morphogenesis
Response To Growth Factor
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Cation Channel Activity
Platelet Activation
Cell-cell Signaling
Nerve Growth Factor Processing
Pathogenesis
Neurotrophin TRK Receptor Signaling Pathway
Tagcloud
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Difference)
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Intersection)
?