PPP1R12C and USHBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPP1R12C	USHBP1
Description		protein phosphatase 1 regulatory subunit 12C	USH1 protein network component harmonin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding	Protein Binding PDZ Domain Binding
	Biological Process	Signal Transduction Neuron Projection Morphogenesis
Pathways
Drugs
Diseases
GWAS			Mitochondrial DNA copy number ( 30704525)
Interacting Genes		27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1	234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AIRIM AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf216 C21orf58 CBY2 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DNAAF19 DRC4 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1
Entrez ID		54776	83878
HPRD ID		11452	18276
Ensembl ID		ENSG00000125503	ENSG00000130307
Uniprot IDs		Q9BZL4	B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Protein Binding Cytoskeleton Organization Intermediate Filament Microtubule-based Process Organelle Organization Structural Molecule Activity Microtubule Cytoskeleton Organization Centrosome Supramolecular Fiber Organization Cytoplasm Structural Constituent Of Cytoskeleton Spindle Pole Establishment Of Spindle Orientation Microtubule Organizing Center Organization Establishment Of Mitotic Spindle Orientation Epithelial Cell Differentiation Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Motile Cilium Organelle Localization Chromosome, Centromeric Region Centriole Kinetochore Microtubule-based Movement Positive Regulation Of Ubiquitin-dependent Endocytosis Morphogenesis Of An Epithelium Microtubule Axonemal A Tubule Inner Sheath Negative Regulation Of Cell Cycle Phase Transition Establishment Of Organelle Localization Membrane Fission Protein Deneddylation CENP-A Containing Chromatin Assembly Ciliary Basal Body Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cis-Golgi Network Centrosome Cycle Regulation Of Post-translational Protein Modification Cilium Movement Centriole Assembly Cilium
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