PPP1R12C and MPRIP

Number of citations of the paper that reports this interaction (PMID 14506264)
22

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PPP1R12C	MPRIP
Gene Name		protein phosphatase 1, regulatory subunit 12C	myosin phosphatase Rho interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Focal Adhesion Actin Cytoskeleton
	Molecular Function	Protein Binding	Actin Binding Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: ATXN7 C1orf109 CACNA1A CDC42BPA IL16 MPRIP MYL2 PAFAH1B2 PPP1CB RBM17 SMAD3	13 interactors: ATXN7 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C RACGAP1 RHOA YTHDC1 YWHAB YWHAG YWHAQ
Entrez ID		54776	23164
HPRD ID		11452	17591
Ensembl ID		ENSG00000125503	ENSG00000133030
Uniprot IDs		B4DME2 Q9BZL4	Q6WCQ1 Q8N236
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Positive Chemotaxis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cerebellar Molecular Layer Development Positive Regulation Of Transforming Growth Factor Beta3 Production Muscle Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chemotaxis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Vestibular Nucleus Development Actomyosin Structure Organization Positive Regulation Of Behavior Regulation Of Chemotaxis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Evasion Or Tolerance Of Host Defenses By Virus Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Gamma-aminobutyric Acid Secretion Negative Regulation Of Cell Growth Regulation Of Extracellular Matrix Assembly Regulation Of Acetylcholine Secretion, Neurotransmission Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Rhythmic Synaptic Transmission Primary MiRNA Processing Response To Transforming Growth Factor Beta Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Glycogen Catabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Heart Morphogenesis Response To External Stimulus Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Transforming Growth Factor Beta2 Production Chloride Ion Homeostasis Transdifferentiation Gamma-aminobutyric Acid Transport Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Lipid Catabolic Process Positive Regulation Of Catenin Import Into Nucleus Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Pons Development	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Mitotic Spindle Assembly Regulation Of Cell Death Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Substantia Nigra Development Positive Regulation Of Cytokinesis Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Death Mitotic Spindle Organization Signaling Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cell Communication Neural Nucleus Development Positive Regulation Of Transport Mitotic Cell Cycle Regulation Of Cytokinesis Microtubule-based Process Mitotic Nuclear Division Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Catalytic Activity Apoptotic Signaling Pathway Spindle Assembly Positive Regulation Of Cellular Metabolic Process
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