PPP1R12C and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPP1R12C	PAFAH1B2
Gene Name		protein phosphatase 1, regulatory subunit 12C	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process		Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		11 interactors: ATXN7 C1orf109 CACNA1A CDC42BPA IL16 MPRIP MYL2 PAFAH1B2 PPP1CB RBM17 SMAD3	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		54776	5049
HPRD ID		11452	03940
Ensembl ID		ENSG00000125503	ENSG00000168092
Uniprot IDs		B4DME2 Q9BZL4	P68402
PDB IDs			1VYH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Positive Chemotaxis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cerebellar Molecular Layer Development Positive Regulation Of Transforming Growth Factor Beta3 Production Muscle Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chemotaxis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Vestibular Nucleus Development Actomyosin Structure Organization Positive Regulation Of Behavior Regulation Of Chemotaxis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Evasion Or Tolerance Of Host Defenses By Virus Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Gamma-aminobutyric Acid Secretion Negative Regulation Of Cell Growth Regulation Of Extracellular Matrix Assembly Regulation Of Acetylcholine Secretion, Neurotransmission Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Rhythmic Synaptic Transmission Primary MiRNA Processing Response To Transforming Growth Factor Beta Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Glycogen Catabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Heart Morphogenesis Response To External Stimulus Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Transforming Growth Factor Beta2 Production Chloride Ion Homeostasis Transdifferentiation Gamma-aminobutyric Acid Transport Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Lipid Catabolic Process Positive Regulation Of Catenin Import Into Nucleus Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Pons Development	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?