PPP1R12C and TSFM

Number of citations: 47 (PubMedID 25910212)
Data Source: BioGRID (two hybrid)

		PPP1R12C	TSFM
Name		protein phosphatase 1 regulatory subunit 12C	Ts translation elongation factor, mitochondrial
Structure		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton	Nucleoplasm Mitochondrion Intracellular Organelle Lumen
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding	RNA Binding Translation Elongation Factor Activity Protein Binding
	Biological Process	Signal Transduction Neuron Projection Morphogenesis	Translation Translational Elongation Mitochondrial Translational Elongation
Pathways		None	Mitochondrial translation elongation
Diseases		None	Combined oxidative phosphorylation deficiency (COXPD)
GWAS		No GWAS studies recorded	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Brain morphology (MOSTest) ( 32665545 ) Multiple sclerosis ( 24076602 )
Novel Interactors		None recorded	1 novel interactors: AGPS
Interacting Genes		27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1	12 interacting genes: CCDC89 CDC42 CEP70 CPLX2 DRC4 GOLGA6L9 KRTAP1-1 LIG4 MDFI MTRNR2L1 PPP1R12C RALBP1
Entrez ID		54776	10102
HPRD ID		11452	05285
Ensembl ID		ENSG00000125503	ENSG00000123297
Uniprot IDs		Q9BZL4	E5KS95 P43897
PDB IDs		Not available	2CP9
GO Terms Enriched among Interactors		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation	None