PPP1R12C and MYL2

Number of citations: 0 (PubMedID 11399775)
Data Source: HPRD (in vitro, in vivo)

		PPP1R12C	MYL2
Name		protein phosphatase 1 regulatory subunit 12C	myosin light chain 2
Structure		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	Signal Transduction Neuron Projection Morphogenesis	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways		None	Striated Muscle Contraction
Diseases		None	Hypertrophic cardiomyopathy (HCM)
GWAS		No GWAS studies recorded	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Alcohol consumption (max-drinks) ( 29460428 ) Body mass index ( 24861553 ) Coffee consumption ( 29367735 ) Coronary heart disease ( 23364394 ) Drinking behavior ( 23364009 ) Gamma glutamyl transpeptidase ( 21909109 ) Glycemic traits ( 23575436 ) Gout ( 25646370 ) HDL cholesterol ( 21909109 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Metabolic syndrome ( 25705158 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Neutrophil count ( 29403010 ) Serum uric acid levels ( 32514006 ) Urate levels ( 31578528 ) White blood cell count ( 29403010 )
Interacting Genes		27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		54776	4633
HPRD ID		11452	01181
Ensembl ID		ENSG00000125503	ENSG00000111245
Uniprot IDs		Q9BZL4	A0A590UJU8 G3V1V8 P10916 Q6IB42
PDB IDs		Not available	5TBY 8ACT 8G4L
GO Terms Enriched among Interactors		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation	Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy