PDP1 and PLEKHF2

		PDP1	PLEKHF2
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	pleckstrin homology and FYVE domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex
Drugs
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Radiation response ( 20923822)
Interacting Genes		11 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PRKCD SIRT3	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		54704	79666
HPRD ID		16185	15147
Ensembl ID		ENSG00000164951	ENSG00000175895
Uniprot IDs		Q6P1N1 Q9P0J1	Q9H8W4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Salivary Gland Morphogenesis Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Lipid Metabolic Process Enzyme Binding Acetyl-CoA Metabolic Process Gland Morphogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Lipid Biosynthetic Process Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metanephric Proximal Convoluted Tubule Development Epithelium Development Propionyl-CoA Biosynthetic Process Transferase Activity C-acetyltransferase Activity Positive Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Signaling Multivesicular Body, Internal Vesicle Lumen Regulation Of Catalytic Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of DNA Metabolic Process Tissue Development Kidney Epithelium Development Positive Regulation Of Phosphate Metabolic Process Shc-EGFR Complex Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Regulation Of Lateral Mesodermal Cell Fate Specification Regulation Of Lipid Metabolic Process Regulation Of Amide Metabolic Process Positive Regulation Of Sphingomyelin Catabolic Process	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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