PDP1 and CBFA2T2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDP1	CBFA2T2
Gene Name		pyruvate dehyrogenase phosphatase catalytic subunit 1	core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Cellular Metabolic Process Small Molecule Metabolic Process	Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CBFA2T2 PDHA1 PRKCD	23 interactors: APP ATN1 ATXN1L CBFA2T3 CBFB FBXL19 GTF2E1 ID3 LBP MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 PDP1 PRDM14 RERE RUNX1 SIN3A TAL2 TCP1 WDYHV1 ZNF652
Entrez ID		54704	9139
HPRD ID		16185	04721
Ensembl ID		ENSG00000164951	ENSG00000078699
Uniprot IDs		Q6P1N1 Q9P0J1	O43439
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Projection Organization Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Interleukin-10 Production Negative Regulation Of Filopodium Assembly Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Lipid Metabolic Process Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Cellular Ketone Metabolic Process Regulation Of Superoxide Anion Generation Regulation Of Platelet Aggregation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Negative Regulation Of Platelet Activation Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Protein Dephosphorylation Neutrophil Activation Acetyl-CoA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Lipid Catabolic Process Regulation Of Platelet Activation Cellular Senescence Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Proliferation Tricarboxylic Acid Cycle Negative Regulation Of Peptidyl-tyrosine Phosphorylation Citrate Metabolic Process Regulation Of Filopodium Assembly Peptidyl-threonine Phosphorylation Positive Regulation Of Dephosphorylation Activation Of Phospholipase C Activity Negative Regulation Of Blood Coagulation Tricarboxylic Acid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Regulation Of Lipid Catabolic Process Negative Regulation Of Coagulation Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process Aerobic Respiration	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Multicellular Organismal Development Nitrogen Compound Metabolic Process Biosynthetic Process Organ Development Definitive Hemopoiesis Central Nervous System Development Developmental Process System Development Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Forebrain Development DNA-templated Transcription, Initiation Metabolic Process Embryo Development Negative Regulation Of Cellular Metabolic Process Myeloid Cell Differentiation Thalamus Development In Utero Embryonic Development Nervous System Development Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		acat1 acetyltransferase aerobic attached attenuate attenuation catabolize concert covalently dehydrogenase dihydrolipoyl dissociates glycolysis l2 lipoic pdc pdh pdha1 pdk pyruvate recruit recruits rely sirt3 switch tyr warburg y94f
Tagcloud (Difference) ?		acat1 acetyltransferase aerobic attached attenuate attenuation catabolize concert covalently dehydrogenase dihydrolipoyl dissociates glycolysis l2 lipoic pdc pdh pdha1 pdk pyruvate recruit recruits rely sirt3 switch tyr warburg y94f
Tagcloud (Intersection) ?