PDP1 and PDHA1

Number of citations of the paper that reports this interaction (PMID 7782287)
14

Data Source:
HPRD (in vitro)

		PDP1	PDHA1
Gene Name		pyruvate dehyrogenase phosphatase catalytic subunit 1	pyruvate dehydrogenase (lipoamide) alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Nucleus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Metal Ion Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity
	Biological Process	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Glycolytic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CBFA2T2 PDHA1 PRKCD	8 interactors: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		54704	5160
HPRD ID		16185	02420
Ensembl ID		ENSG00000164951	ENSG00000131828
Uniprot IDs		Q6P1N1 Q9P0J1	P08559
PDB IDs			1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Projection Organization Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Interleukin-10 Production Negative Regulation Of Filopodium Assembly Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Lipid Metabolic Process Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Cellular Ketone Metabolic Process Regulation Of Superoxide Anion Generation Regulation Of Platelet Aggregation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Negative Regulation Of Platelet Activation Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Protein Dephosphorylation Neutrophil Activation Acetyl-CoA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Lipid Catabolic Process Regulation Of Platelet Activation Cellular Senescence Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Proliferation Tricarboxylic Acid Cycle Negative Regulation Of Peptidyl-tyrosine Phosphorylation Citrate Metabolic Process Regulation Of Filopodium Assembly Peptidyl-threonine Phosphorylation Positive Regulation Of Dephosphorylation Activation Of Phospholipase C Activity Negative Regulation Of Blood Coagulation Tricarboxylic Acid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Regulation Of Lipid Catabolic Process Negative Regulation Of Coagulation Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process Aerobic Respiration	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Insulin Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cellular Response To Oxygen Levels Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Response To Hormone Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration Cellular Response To Acid Chemical Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		acat1 acetyltransferase aerobic attached attenuate attenuation catabolize concert covalently dehydrogenase dihydrolipoyl dissociates glycolysis l2 lipoic pdc pdh pdha1 pdk pyruvate recruit recruits rely sirt3 switch tyr warburg y94f	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Difference) ?		acat1 acetyltransferase aerobic attached attenuate attenuation catabolize concert covalently dehydrogenase dihydrolipoyl dissociates glycolysis l2 lipoic pdc pdh pdk pyruvate recruit recruits rely sirt3 switch tyr warburg y94f	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Intersection) ?		pdha1