PDP1 and SIRT3

Number of citations of the paper that reports this interaction (PubMedID 24486017)
33

Data Source:
BioGRID (pull down)

		PDP1	SIRT3
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	sirtuin 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent Enzyme Binding Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Sequence-specific DNA Binding Metal Ion Binding NAD+ Binding NAD-dependent Protein Lysine Delactylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation	Protein Deacetylation Aerobic Respiration Positive Regulation Of Insulin Secretion Cellular Response To Stress Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex	Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Mitochondrial unfolded protein response (UPRmt) Maturation of TCA enzymes and regulation of TCA cycle
Drugs			Adenosine-5-Diphosphoribose
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		11 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PRKCD SIRT3	11 interacting genes: ALDH2 DNM1L ECHS1 GLDC H3C1 MCL1 MDM2 PDP1 PEX5 PYCR1 XRCC6
Entrez ID		54704	23410
HPRD ID		16185	06836
Ensembl ID		ENSG00000164951	ENSG00000142082
Uniprot IDs		Q6P1N1 Q9P0J1	E9PK80 E9PM75 E9PN58 Q9NTG7
PDB IDs			3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO 8ANC 8BBK 8CCW 8CCZ 8HLW 8HLY 8HN9 8V15 8V2N 8V5U 9CBT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Salivary Gland Morphogenesis Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Lipid Metabolic Process Enzyme Binding Acetyl-CoA Metabolic Process Gland Morphogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Lipid Biosynthetic Process Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metanephric Proximal Convoluted Tubule Development Epithelium Development Propionyl-CoA Biosynthetic Process Transferase Activity C-acetyltransferase Activity Positive Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Signaling Multivesicular Body, Internal Vesicle Lumen Regulation Of Catalytic Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of DNA Metabolic Process Tissue Development Kidney Epithelium Development Positive Regulation Of Phosphate Metabolic Process Shc-EGFR Complex Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Regulation Of Lateral Mesodermal Cell Fate Specification Regulation Of Lipid Metabolic Process Regulation Of Amide Metabolic Process Positive Regulation Of Sphingomyelin Catabolic Process	Mitochondrion Mitochondrial Matrix Cellular Response To Chemical Stress Protein-containing Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Lyase Activity Cellular Response To Gamma Radiation Electron Transfer Activity Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process 3-hydroxypropionyl-CoA Dehydratase Activity Fatty Acid Beta-oxidation Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Response To Gamma Radiation Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Formaldehyde Cellular Response To Oxidative Stress Cellular Response To Vitamin B1 Endoplasmic Reticulum Organization Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Carboxylic Acid Metabolic Process Apoptotic Mitochondrial Changes Organic Acid Metabolic Process Cellular Response To Ionizing Radiation Small Molecule Metabolic Process Fatty Acid Catabolic Process Crotonyl-CoA Hydratase Activity Fatty Acid Oxidation Response To Lipoic Acid Protein Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Lipid Oxidation Response To Oxidative Stress DNA End Binding Cellular Response To Stress Ku70:Ku80 Complex Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Glycine Catabolic Process
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